| p57kip2 mRNA在肝细胞癌发生过程中的表达 |
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| 引用本文： | 孔萌萌,金克炜,申丽娟,章宗籍,张华献,孙江华. p57kip2 mRNA在肝细胞癌发生过程中的表达[J]. 昆明医学院学报, 2007, 28(3): 10-12,24 |
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| 作者姓名： | 孔萌萌 金克炜 申丽娟 章宗籍 张华献 孙江华 |
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| 作者单位： | 1. 同济大学生命科学与技术学院肿瘤研究所,上海,200092
2. 昆明医学院病理教研室,云南,昆明,650031 |
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| 摘 要： | 目的研究p57^kip2 mRNA在人体肝细胞癌发生不同阶段的表达状况,探讨与肝癌发生发展及分化的关系.方法采用原位分子杂交技术检测正常肝组织、慢性肝炎、肝硬化、癌周肝硬化和肝细胞癌共42例标本中p57^kip2 mRNA的表达.结果正常肝组织组未见p57^kip2 mRNA表达,慢性肝炎组阳性表达率为57.14%（4/7）,肝硬化组阳性表达率为40.00%（4/10）,癌周肝硬化组与肝癌组阳性表达率分别为70.00%（7/10）和20.00%（2/10）.肝癌组p57^kip2 mRNA阳性表达率明显下降,与癌周肝硬化组差异有统计学意义（P〈0.05）.肝癌组分化好者与分化差者表达差异有统计学意义（P〈0.05）.结论p57^kip2 mRNA表达下降在原发性肝癌的发生发展中起着重要作用,且可能与肝癌的分化有关.
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| 关 键 词： | 肝细胞癌 肝炎 肝硬化 原位杂交 |
| 文章编号： | 1003-4706（2007）03-0010-03 |
| 修稿时间： | 2006-11-08 |
Expression of p57kip2 mRNA in Human Hepatocarcinogenesis |
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| KONG Meng-meng,JIN Ke-wei,SHEN Li-juan,ZHANG Zong-ji,ZHANG Hua-xian,SUN Jiang-hua. Expression of p57kip2 mRNA in Human Hepatocarcinogenesis[J]. Journal of Kunming Medical College, 2007, 28(3): 10-12,24 |
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| Authors: | KONG Meng-meng JIN Ke-wei SHEN Li-juan ZHANG Zong-ji ZHANG Hua-xian SUN Jiang-hua |
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| Affiliation: | 1 Institute of Cancer Research, School of Life Science and Technology, Tongji University, Shanghai 200092 ; 2 Dept. of Pathology, Kunming Medical College, Kunming 650031, China |
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| Abstract: | Objective To study the expression of p57kip2 mRNA during different phases of hepatocarcinogenesis and to explore their relationships with the occurrence, development and differentiation of hepatocarcinoma. Methods In situ hybridization (ISH) for p57kip2 mRNA was performed in formalin-fixed and paraffin-embedded sections in 88 cases of normal liver tissue(n=10), chronic hepatitis(n=18), liver cirrhosis(n=20), paracancerous cirrhosis(n=18) and hepatocellular carcinoma(n=22). Results The positive rate of p57kip2 mRNA was 57.14%(4/7) in chronic hepatitis, 40.00%(4/10) in liver cirrhosis, 70.00%(7/10) in paratumor cirrhosis and 20.00%(2/10) in hepatocellular carcinoma respectively. The expression of p57kip2 mRNA in paratumor cirrhosis was significantly higher than that in hepatocellular carcinoma (P<0.05). And there was statistical difference of the expression of p57kip2 mRNA between well differentiated hepatocellular carcinoma and that of poorly differentiated hepatocellular carcinoma (P<0.05). Conclusion The decrease of p57kip2 mRNA in hepatocellular carcinoma indicates that p57kip2 may be involved in human hepatocarcinogenesis and its differentiation. |
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| Keywords: | p57kip2 |
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