翼状胬肉术后应用环孢素和氟尿嘧啶的临床对比观察

目的:观察翼状胬肉术后应用环孢素或氟尿嘧啶的临床疗效和安全性。方法:将102例(131眼)翼状胬肉术后患者按随机数字表法分为对照组(50例65眼)和治疗组(52例66眼)。所有患者行翼状胬肉术后,对照组患者给予氟尿嘧啶0.2 ml,球结膜下注射,1次/周,连用4周;治疗组患者给予环孢素滴眼液滴眼,1滴/次,4次/d,连用12周。观察两组患者临床疗效及复发率、角膜和结膜的愈合时间及不良反应发生情况。结果:治疗后,两组患者总有效率、复发率、角膜和结膜愈合时间比较差异均无统计学意义(P>0.05);对照组患者不良反应发生率显著高于治疗组,两组比较差异有统计学意义(P<0.05)。结论 :翼状胬肉术后应用环孢素或氟尿嘧啶均具有显著疗效,但环孢素较氟尿嘧啶安全性更高。

Comparative Observation of the Application of Ciclosporin and Fluorouracil after Pterygium Surgery

OBJECTIVE： To observe clinical efficacy and safety of cyclosporine and fluorouracil after pterygium surgery. METHODS： 102 patients underwent pterygium surgery with 131 eyes were randomly divided into control group （65 eyes of 50 cases） and treatment group （66 eyes of 52 cases）. Control group received conjunctival injection of fluorouracil 0.2 ml, once a week, for consecutive 4 weeks; treatment group were treated with Cyclosporin eye drops, 1 drop/time, 4 times/d, for consecutive 12 weeks. The clinical efficacy, relapse rate, time of corneal and conjunctival healing and ADR were observed in 2 groups. RESULTS： There was no statistical significance in total effective rate, relapse rate, time of cornea and conjunctiva healing between 2 groups （P〉0.05） ; the incidence of ADR in control group was significantly higher than that of treatment group; there was statistical significance （P〈0.05）. CONCLUSIONS： The application of cyclosporine and fluorouracil after pterygium surgery show good therapeutic efficacy, but cyclosporine has a higher security.