T cell immunosenescence in vitro and in vivo. |
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| Authors: | G Pawelec W Wagner M Adibzadeh A Engel |
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| Affiliation: | 1. Lab of Physiopharmacology, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium;2. Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium;3. Department of Thoracic and Vascular Surgery, ZNA Middelheim (Ziekenhuis Netwerk Antwerpen), Lindendreef 1, B-2020 Antwerp, Belgium;4. Department of Thoracic and Vascular Surgery, Antwerp University Hospital (UZA), Wilrijkstraat 10, B-2650 Edegem, Antwerp, Belgium;1. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA;2. Department of Medicine, University of North Carolina, Chapel Hill, NC, USA;3. Department of Cardiac Surgery, Vanderbilt University, Nashville, TN, USA;4. Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD, USA;5. Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA |
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| Abstract: | ![]()
The term "immunosenescence" refers to an age-associated dysregulation of immune function which contributes to the increased susceptibility of the elderly to infectious disease. Although there are age-associated changes measurable in the innate immune system (Pawelec et al., 1998c), it is the adaptive, particularly T cell, system which is most susceptible to the deleterious effects of aging. In this minireview, characteristics of aging in long-term human T cell cultures will be summarized, and the parallels between the in vitro model and in vivo immunosenescence will be documented. The use of culture models to screen for ways of manipulating immunosenescence in vitro may provide a basis for intervention to ameliorate immunosenescence in vivo. |
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