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Early stage chronic lymphocytic leukaemia carrying unmutated IGHV genes is at risk of recurrent infections during watch and wait |
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| Authors: | Rossi Davide De Paoli Lorenzo Rossi Francesca M Cerri Michaela Deambrogi Clara Rasi Silvia Zucchetto Antonella Capello Daniela Gattei Valter Gaidano Gianluca |
| Affiliation: | Division of Haematology, Department of Clinical and Experimental Medicine &Centre of Biotechnologies for Applied Medical Research, Amedeo Avogadro University of Eastern Piedmont and Ospedale Maggiore della Carità, Novara;, and Clinical and Experimental Onco-Haematology Unit, Centro di Riferimento Oncologico, I.R.C.C.S., Aviano (PN), Italy. E-mail: |
| Abstract: | Ischemic stroke is associated with leucocyte activation. Activated leucocytes release elastase, an enzyme that can degrade fibrinogen. Fibrinogen elastase degradation products (FgEDP) may serve as a specific marker of elastase proteolytic activity. In a case‐control study of 111 ischemic stroke patients and 119 controls, significantly higher FgEDP levels were observed in cases than in controls, both in the acute phase and in the convalescent phase. Results were only slightly affected by adjustment for cardiovascular risk factors, C‐reactive protein and fibrinogen. Our findings suggest that FgEDP might be involved in the pathogenesis of stroke. |
| Keywords: | chronic lymphocytic leukaemia infection immunoglobulin genes risk factors immunodeficiency |
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