隐匿性乙型肝炎病毒感染者临床特点和肝组织病理学检查

目的了解血清肝炎病毒标志物阴性、肝功能反复异常患者中HBV隐匿性感染的比例及其临床和病理学特点。方法对27例血清肝炎病毒标志物阴性、肝功能反复异常患者采用免疫组化法检测肝组织HBsAg、HBcAg和HCVAg，并进行常规的病理学检查。结果肝组织HBsAg和（或）HBcAg阳性9例（33．3％）；HBsAg和（或）HBcAg及HCVAg阳性10例（37．0％）；全阴性8例（29．6％）。在HBV隐匿性感染的19例患者中，慢性肝炎8例，肝硬化11例。结论HBV和HCV感染为血清肝炎病毒标志物阴性患者肝功能反复异常的主要原因之一，尤其是HBV感染。这种HBV隐匿性感染与慢性肝炎、肝硬化的发生关系密切，应引起重视。

Pathological and clinical characteristics in occult infection of hepatitis B virus

Objective To investigate the incidence and pathological and clinical characteristics of occult hepatitis B virus infection in patients with negative serological markers but with abnormal liver function tests. Metheds 27 patients with negative serological markers but with abnormal liver function were enrolled in the study. The express of HBsAg,HBcAg,HCVAg in liver tissues with immunohistochemistry and liver histology was analyzed. Result In 27 patients,there were 9 cases with HBsAg and HBcAg positive,10 cases with HBsAg and HBcAg and HCV antigen positive,and 8 cases with HBsAg and HBcAg and HCV antigen negative. In 19 patients who had HBV occult infection,there were 8 cases with chronic hepatitis,and 11 with liver cirrohosis. Conclusion Occult HBV and HCV infection may account for a high proportion of occult liver function abnormality. Occult HBV infection may induce chronic hepatitis and liver cirrhosis. [