The value of intrauterine insemination with washed husband's sperm in the treatment of infertility

Twenty-nine infertile couples were treated by intrauterine insemination(IUI)of washed sperm from a sub-fertile husband (n = 16), incases of gynaecological (n = 3), combined (n = 4) or idiopathic(n = 6) infertility; 116 treatment cycles redted in 11 ongoingpregnancies. Between 0.25 and 0.45 ml of capacitation medium,containing at least 500 000 pretreated spermatozoa, were inseminated.Pretreatment of first split fractions was performed by centrifugationand swimming up of motile spermatozoa. The pregnancy per cycleindex (P/C) for IUI was 9.5% for a total of 37.9% of all couplestreated achieving pregnancy. These results suggest a substantialbenefit compared with a calculated six months' cumulative pregnancyrate of 4.2% independent of treatment, for this infertile population.The value of IUI in selected cam of infertility seems obviousbut needs further investigation.