C反应蛋白与慢性阻塞性肺疾病的急性加重期关系的探讨

目的 :探讨C反应蛋白 (CRP)在判断老年慢性阻塞性肺疾病 (COPD)的急性加重期时的作用。方法 :检测慢性阻塞性肺疾病的急性加重期的 4 5名老年患者C反应蛋白、白细胞计数、血沉、体温和临床表现 ,并进行比较 ;同时给予抗生素治疗 ,并比较治疗前后这些指标的变化情况。结果 :C反应蛋白在患者入院时的阳性率为 95 5 6 % ,明显高于其他常规指标 ,并与临床的症状和体征相一致。在治疗后 ,CRP在常规检测指标还未有显著变化时已经明显下降 ,其治疗前后的差异具有统计学意义 (P <0 0 1)。结论 :CRP作为反映细菌性感染的敏感指标 ,对COPD急性加重期的早期发现、反映抗生素疗效方面具有重要意义。

The Relationship of C-reactive Protein and Acute Phase of Chronic Obstructive Pulmonary Disease

Objectve:To study the significance of CRP in diagnosis of the acute phase of COPD.Method:CRP, WBC, ESR and body temperature were measured both when the old patients just visited and after the treatment with effective antibiotics to compare their change.Results:The positive rate of CRP is higher than other items, and the difference was obvious (p<0.01). At the same time, the CRP's difference between before and after the use of antibiotics was also obvious (p<0.01) and its change came earlier than others.Conclusion:CRP is a sensitive and specific index to the acute phase of COPD, and is helpful to discover this acute disease early as well as a good guide to the use of antibiotics.