| 石杉碱甲缓释片的研制及释药性质 |
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| 引用本文： | 孔晓龙,蒋伟哲.石杉碱甲缓释片的研制及释药性质[J].广西医科大学学报,2004,21(2):201-202. |
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| 作者姓名： | 孔晓龙 蒋伟哲 |
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| 作者单位： | 广西医科大学第一附属医院药剂科,南宁,530021 |
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| 基金项目： | 广西科技厅基金资助项目 (科攻自 0 0 15 0 19) |
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| 摘 要： | 目的：制备石杉碱甲缓释片，并评价其释药特性。方法：以高分子材料作为阻滞剂．设计处方制备缓释片．并测定其体外释放度。结果：制备的石杉碱甲缓释片1h内释药达32％。12h内释药达86％以上，具有较好的释药性能。结论：该制剂体外释药行为符合Higuchi方程，符合水凝胶骨架释放机理．是较好释药性能的缓释片。
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| 关 键 词： | 石杉碱甲 缓释片 释放度 释药动力学 |
| 修稿时间： | 2003年12月22 |
PREPARATION AND RELEASE PROPERTIES OF SUSTAINED RELEASE HUPERZINEA TABLET |
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| Kong Xiaolong,Jiang Weizhe..PREPARATION AND RELEASE PROPERTIES OF SUSTAINED RELEASE HUPERZINEA TABLET[J].Journal of Guangxi Medical University,2004,21(2):201-202. |
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| Authors: | Kong Xiaolong Jiang Weizhe |
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| Abstract: | Objective:To prepare sustained release huperzine A tablet and evaluate its of drug release property.Methods:The formulation were designed with different ratio.and their release tested respectively.Result:The sustained release huperzine A tablet showed a good release of 32% in the first hour and 86% in twelve hours.Conclusion:The behavior of the tablets followes higuchi kinetics and mechanism of the gel matrix. |
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| Keywords: | huperzine-A sustained release tablets release release kinetics |
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