贝那普利联合氨氯地平治疗糖尿病合并高血压疗效观察

目的探讨贝那普利联合氨氯地平治疗糖尿病合并高血压的临床效果。方法将糖尿病合并高血压患者126例随机分为联合治疗组、贝那普利组和氨氯地平组各42例。联合用药组给予贝那普利片10mg+苯磺酸氨氯地平片5mg治疗,贝那普利组给予贝那普利片20mg治疗,氨氯地平组给予苯磺酸氨氯地平片5mg治疗。比较3组患者治疗前后血压、24h尿微量白蛋白水平及不良反应情况。结果联合治疗组血压和24h尿微量白蛋白下降程度较单独用药组更加明显,差异有统计学意义(P<0.05);且3组均无不良反应。结论贝那普利联合氨氯地平可有效控制糖尿病合并高血压患者的临床症状,具有明显的肾脏保护作用,较单一用药效果好,无明显不良反应,值得临床推广应用。

Effect observation of benazepril combined with amlodipine in diabetes mellitus with hypertension

Objective To discuss the clinical effect of benazepril combined with amlodipine in diabetes mellitus with hypertension.Methods 126 cases patients of diabetes mellitus with hypertension were randomly divided into combination therapy group,benazepril group and amlodipine group,each of 42 cases.Combination therapy group were treated with benazepril tablets 10mg+amlodipine besylate tablets 5mg treatment,benazepril group were given benazepril tablets 20mg therapy,amlodipine group were treated with amlodipine besylate tablets 5mg treatment.Before and after treatment,compared blood pressure,24h urinary albumin level and adverse reaction of three groups.Results Blood pressure and the decreasing degree of 24h urinary albumin of combination therapy group were more obvious than those of the single drug group,the difference were statistically significant(P<0.05);And no adverse reaction happened of three groups.Conclusion Benazepril combined with amlodipine can effectively control the clinical symptom of diabetes mellitus with hypertension patient,has a significant renoprotective effect,nice effect than the single drug,no significant adverse reaction,is worthy of clinical application.