Relationship between Intracranial Granulomas and Cerebrospinal Fluid Levels of Gamma Interferon and Interleukin-10 in Patients with Tuberculous Meningitis |
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| Authors: | Adel M. Mansour Robert W. Frenck Jr. Toni Darville Isabelle A. Nakhla Thomas F. Wierzba Yehia Sultan Magdy I. Bassiouny Kathryn McCarthy Richard F. Jacobs |
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| Affiliation: | University of Arkansas for Medical Sciences, Little Rock, Arkansas,2. U.S. Naval Medical Research Unit No. 3,1. Ministry of Health and Population,3. Abbassia Fever Hospital, Cairo, Egypt4. |
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| Abstract: | Cerebrospinal fluid gamma interferon (IFN-γ) and interleukin-10 levels in 39 patients with tuberculous meningitis were serially measured. Cytokine levels did not predict intracranial granuloma (IG) development, but IFN-γ levels in the top quartile after 1 month of therapy were highly associated (odds ratio = 18) with detection of an IG by computed tomography scanning. |
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