粤籍汉族多囊卵巢综合征遗传流行病学研究

目的分析多囊卵巢综合征（PCOS）的遗传流行病学特征。方法采用调查表的方式对324例PCOS患者及其家系进行调查,同时结合临床检查。应用SPSS13.0软件、Falconer公式对资料进行统计学处理和分析。结果PCOS患者的月经稀发发生率为74.23%,高雄激素血症者占52.71%,卵巢多囊样改变者占93.27%;PCOS组及对照组一级亲属女性月经稀发发生率分别为17.81%和7.70%,男性早秃发生率为别为11.15%和5.33%,先证者家系的月经稀发和男性早秃患病率高于对照者家系;先证者一级亲属遗传度为44.91%。结论遗传因素在PCOS的发病中起着重要作用,但环境因素可能也起着重要的作用。

A Genetic Epidemiology Study of Polycystic Ovary Syndrome of Chinese Han Ethnic Women in Guangdong Province

Objective Analyze genetic epidemiological characteristics of PCOS in Guangdong province.Methods Data for 324 patients with PCOS were obtained by questionnaire,combined with clinical test.Statistic analysis was performed using SPSS 13.0 and the Falconer method.Results The ratio of oligomenorrhoea of PCOS was 74.23%,the ratio of androgen excess was 52.71%,and 93.27% patients were diagnosed by the ultrasound with polycystic ovaries.The prevalence rates of oligomenorrhoea among the first relatives for probands and controls were 17.81% and 7.70%, respectively and with male alopecia was 11.15% and 5.33%, respectively. The prevalence rate of probands in first relatives was significantly higher than that in controls. The heritability of first degree relatives of prohands was 44.91%. Conclusion The effect of genetic factors is strong in PCOS, but other factors such as the impact of environment are also strong.