Multiple synchronous tumors in a child with Fanconi anemia |
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Authors: | Alessia Compostella Pietro Soloni Modesto Carli |
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Affiliation: | a Hematology/Oncology Division, Department of Pediatrics, University Hospital of Padova, 35128 Padova, Italy b Institute of Radiology, University Hospital of Padova, 35128 Padova, Italy c Division of Pediatric Surgery, Department of Pediatrics, University Hospital of Padova, 35128 Padova, Italy |
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Abstract: | Fanconi anemia (FA) is an autosomal recessive inherited syndrome characterized by congenital abnormalities, aplastic anemia, and a high likelihood of developing cancer. We describe a child who presented with 2 synchronous solid tumors (Wilms tumor and neuroblastoma), later found to have FA, who developed severe toxicity and died after a first cycle of chemotherapy. Our experience emphasizes that a predisposing genetic condition should be sought in cases of multiple tumors and that managing FA patients with cancer can be particularly difficult. |
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Keywords: | Synchronous tumors Fanconi anemia Cancer predisposition syndrome Wilms tumor Neuroblastoma |
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