哈萨克族妇女分娩前后抗凝功能检测及临床意义

目的探讨哈萨克族妇女妊娠分娩前后易发深静脉血栓的抗凝方面的因素。方法检测哈萨克族妇女36例、汉族妇女39例分娩前后的蛋白C、蛋白S、抗凝血酶Ⅲ（AT-llI）活性、活化蛋白C抵抗比值（APCR）。结果哈萨克族妇女分娩前后抗凝功能检测蛋白S（43．13±11．36，58．05±17．10）有显著性改变（P〈0．01），哈萨克族妇女分娩后抗凝功能检测值与汉族妇女分娩后比较，蛋白C（97．34±18．37，118．02±23．46）、蛋白S（58．05±17．10，67．97±19．22）差异有统计学意义（P〈0．05，其中蛋白C比较P〈0．01），但哈萨克族妇女分娩后抗凝指标均在正常范围内。结论正常妇女分娩前后存在血栓前状态，哈萨克族妇女亦存在明显的血栓前状态；蛋白C、蛋白S活性较汉族妇女低，可能是其分娩前后易发深静脉血栓的重要因素；分娩前后进行抗凝功能的检测对预防哈萨克族妇女深静脉血栓的形成有一定临床意义。

The detection of anticoagulant function in Kazakh women before and after delivery and clinical significance

Objective To investigate the anticoagulant factors that Kazakh women are prone to develop deep vein thrombosis before or after delivery.Methods The protein C,protein S,antithrombin Ⅲ (AT-Ⅲ) activity,activated protein C resistance ratio (APCR) of 36 Kazakh women cases and 39 Hans women cases before and after delivery were determined.Results The protein S (43.13±11.36,58.05±17.10) was significant changed (P＜0.01)in Kazakh women before and after delivery.The protein C (97.34±18.37,118.02±23.46) and protein S (58.05±17.10,67.97±19.22) were statistically different between Kazakh women and Han women after delivery(P＜0.05,which protein C was P＜0.01).The anticoagulant indexes of Kazak women after delivery was still within normal range.Conclusions Normal women have prothrombotic state before and after delivery,especially the Kazakh women.It may be an important factor of deep vein thrombosis-prone before and after delivery that protein C and protein S in Kazakh women have lower activity than that in Han women.The detection of anti-coagulation have some clinical significance on the prevention of the deep vein thrombosis in Kazakh women before and after delivery.