| 整数非线性规划模型在乳腺癌转移相关基因表达调控网络建立中的应用 |
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| 引用本文： | 罗万春,易东,刘恩,龚利红. 整数非线性规划模型在乳腺癌转移相关基因表达调控网络建立中的应用[J]. 北京生物医学工程, 2008, 27(2): 138-141 |
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| 作者姓名： | 罗万春 易东 刘恩 龚利红 |
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| 作者单位： | 第三军医大学,重庆,400038;重庆通信学院机电教研室,重庆,400035 |
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| 摘 要： | 利用乳腺癌转移基因表达数据的熵信息确定基因权重,建立以误差最小为目标函数的整数非线性规划模型推测基因之间的调控关系,并通过相关系数模型筛选调控基因.利用软件LING08.0和MATLAB7.0编程求解,得到27个乳腺癌转移相关基因的调控网络,其中25对基因存在调控关系,有11对存在相互促进的双向调控作用.整数非线性规划模型能较好地刻划乳腺癌转移相关基因调控关系,可用于更复杂的基因调控网络的研究.
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| 关 键 词： | 乳腺癌 基因调控网络 整数非线性规划模型 |
| 文章编号： | 1002-3208(2008)02-0138-04 |
| 修稿时间： | 2007-07-16 |
The application of INLP model in setting up the regulary networks of gene related to breast cancer metastasis |
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| LUO Wanchun,YI Dong,LIU En,GONG Lihong. The application of INLP model in setting up the regulary networks of gene related to breast cancer metastasis[J]. Beijing Biomedical Engineering, 2008, 27(2): 138-141 |
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| Authors: | LUO Wanchun YI Dong LIU En GONG Lihong |
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| Affiliation: | LUO Wanchun1,YI Dong2,LIU En3,GONG Lihong4 1 Third Military Medical University,Chongqing 400038,2 Department of Machine , Electron,Chongqing Communication College,Chongqing 400035 |
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| Abstract: | The authors utilized the entropy information from genetic data of breast cancer metastasis to get the weights of all the genes,and set up an integer nonlinear programing(INLP) model in which minimum error is regarded as objective function to search for the regulary relation in the genes,and then sieved regulary genes by coefficient correlation model.Using the programs of LINGO8.0 and MATLAB7.0,we got a genetic regulary network of the 27 genes related to breast cancer metastasis,where there are 25 pairs gene... |
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| Keywords: | breast cancer genetic regulatory networks INLP |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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