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| 间充质干细胞治疗激素耐药重度急性移植物抗宿主病 | |
| 引用本文： | 翁建宇,杜欣,项鹏,陆泽生,吴穗晶,郭荣,罗成伟,凌伟,廖鹏军,邓程新,刘晓力. 间充质干细胞治疗激素耐药重度急性移植物抗宿主病[J]. 实用医学杂志, 2010, 26(1). DOI: 10.3969/j.issn.1006-5725.2010.01.037 |
| 作者姓名： | 翁建宇 杜欣 项鹏 陆泽生 吴穗晶 郭荣 罗成伟 凌伟 廖鹏军 邓程新 刘晓力 |
| 作者单位： | 1. 广东省人民医院血液科,广东省医学科学院,广州市,510080 2. 中山大学基因工程与干细胞中心,广州市,510080 3. 南方医科大学南方医院血液科,广州市,510515 |
| 摘 要： | 目的:探讨体外扩增骨髓间充质干细胞(mesenchymal stem cells, MSCs)治疗激素耐药重度急性移植物抗宿主病(acute graft-versus-host disease, aGVHD)的临床疗效和安全性.方法:4例恶性血液病患者经HLA匹配同胞外周血干细胞联合骨髓移植后,诊断为激素耐药重度aGVHD,在原有免疫抑制治疗的基础上给予MSCs 0.5 × 106/kg受者体重.结果:4例患者经静脉输注体外扩增MSCs共9例次,未发现输注相关不良反应.所有患者均显示不同程度的治疗反应,总有效率达100%.4例发生消化道aGVHD,完全缓解2例,显著缓解1例,部分缓解1例.2例合并肝脏aGVHD患者中1例获完全缓解,1例获部分缓解.初始显效和充分显效的中位时间分别为3 d(2 ～ 5 d)和23 d(10 ～ 72 d).MSCs输注后,病情缓解者外周血CD8+CD28- T细胞比例明显上升,而CD8+CD28+ T细胞比例下降.结论:MSCs可快速缓解激素耐药重度aGVHD病情,其可能通过对CD8+CD28-/CD8+CD28+ T细胞比例的调控发挥抗aGVHD的作用. |
| 关 键 词： | 移植物抗宿主病 激素 耐药 急性 间充质干细胞 |
Mesenchymal stem cells as salvage therapy for severe steroid-resistant acute graft-versus-host disease |
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| WENG Jian-yu,DU Xin,XIANG Peng,LU Ze-sheng,WU Sui-jing,GUO Rong,LUO Cheng-wei,LING Wei,LIAO Peng-jun,DENG Cheng-xin,LIU Xiao-li. Mesenchymal stem cells as salvage therapy for severe steroid-resistant acute graft-versus-host disease[J]. The Journal of Practical Medicine, 2010, 26(1). DOI: 10.3969/j.issn.1006-5725.2010.01.037 | |
| Authors: | WENG Jian-yu DU Xin XIANG Peng LU Ze-sheng WU Sui-jing GUO Rong LUO Cheng-wei LING Wei LIAO Peng-jun DENG Cheng-xin LIU Xiao-li |
| Affiliation: | WENG Jian-yu,DU Xin,XIANG Peng,LU Ze-sheng,WU Sui-jing,GUO Rong,LUO Cheng-wei,LING Wei,LIAO Peng-jun,DENG Cheng-xin,LIU Xiao-li.Department of Haematology,Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China |
| Abstract: | Objective To explore the efficacy and safety of mesenchymal stem cells (MSCs) as a treatment for patients with severe steroid-resistant acute graft-versus-host disease (aGVHD). Methods Four patients,who received sibling peripheral blood stem cells and bone marrow transplantations,were diagnosed as severe steroid-resistant aGVHD based on the results of HLA experiment. On the basis of primary therapy with immunosuppressive agents (Cyclosporin A + Methotrexate,Methylprednisolone,Mycophenolate mofetil,Zenapax,e... |
| Keywords: | Graft vs host disease Steroid Resistant Acute Mesenchymal stem cells |
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