尿毒症患者头孢菌素脑病21例临床分析

目的探讨尿毒症患者头孢菌素脑病的发病机制和临床特点、治疗方法。方法对21例尿毒症患者使用的头孢类药物及出现的神经精神症状、发病后治疗进行回顾性分析。结果神经、精神症状表现多种多样。全部患者无神经系统定位体征,CT检查无急性病变,停药后症状消失。结论尿毒症患者使用头孢菌素治疗感染可能引起一过性脑病,其原因与肾脏的排泄功能下降有关。尿毒症患者应用头孢菌素时应注意药物选择、调整剂量,一旦出现症状立即停药处理。

Clinical study on 21 cases of uremic patients with cephalosporin encephalopathy

Objective To study the etiopathology,clinical features and therapy of uremic patients with cephalosporin encephalopathy.Methods A total of 21 uremic patients with cephalosporin encephalopathy were analysed.Results The clinical features were different.The symptom would relieve after suspending cephalosporin therapy.Conclusion Cephalosporin may cause encephalopathy in uremic patients.The kind of cephalosporin and dosage should be adjusted in uremic patients.