| 盐酸戊乙奎醚对体外循环心脏手术患者肺功能的影响 |
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| 引用本文： | 余开峰,潘雪莲,李颖波.盐酸戊乙奎醚对体外循环心脏手术患者肺功能的影响[J].郧阳医学院学报,2010,29(6). |
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| 作者姓名： | 余开峰 潘雪莲 李颖波 |
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| 作者单位： | 余开峰 (湖北医药学院附属人民医院麻醉科,湖北,十堰,442000) ； 潘雪莲 (湖北医药学院附属人民医院麻醉科,湖北,十堰,442000) ； 李颖波 (湖北医药学院附属人民医院麻醉科,湖北,十堰,442000) ； |
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| 摘 要： | 目的:探讨盐酸戊乙奎醚对体外循环(CPB)下心脏手术患者肺功能的影响及可能机制。方法:24例CPB心脏手术患者随机分为对照组和盐酸戊乙奎醚组,于体外循环开始前30 min,分别注射0.9%氯化钠溶液5mL,和盐酸戊乙奎醚0.02 mg/kg。CPB前(T1)、主动脉开放后30 min(T2),CPB结束后4 h(T3)、CPB后24 h(T4)进行血气分析及检测血浆肿瘤坏死因子-α(TNF-α)和白细胞介素6(IL-6)水平,计算肺泡-动脉血氧分压差P(A-a)DO2]和呼吸指数(RI)。结果:2组患者T2、T3、T4时点与T1时点相比,P(A-a)DO2、RI及血浆TNF-α和IL-6浓度均显著升高(P<0.05);盐酸戊乙奎醚组T2、T3、T4时点P(A-a)DO2和RI,及TNF-α和IL-6浓度较对照组均显著降低(P<0.05)。结论:盐酸戊乙奎醚对体外循环下心脏手术患者肺功能有一定的保护作用,其机制可能与其抑制TNF-α和IL-6有关。
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| 关 键 词： | 盐酸戊乙奎醚 体外循环 呼吸指数 P(A-a)DO2 TNF-α IL-6 |
Effects of Penehyclidine Hydrochloride on Lung Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass |
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| YU Kai-feng; PAN Xue-lian; LI Ying-bo.Effects of Penehyclidine Hydrochloride on Lung Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass[J].Journal of Yunyang Medical College,2010,29(6). |
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| Authors: | YU Kai-feng; PAN Xue-lian; LI Ying-bo |
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| Institution: | YU Kai-feng; PAN Xue-lian; LI Ying-bo (Department of Anesthesiology; Renmin Hospital; Hubei University of Medicine; Shiyan; Hubei 442000; China); |
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| Abstract: | Objective To study the effects of penehyclidine hydrochloride on lung fuction in patients undergoing cardiac surgery with cardiopulmonary bypass(CPB) and its possible mechanism.Methods Twenty-four cardiac surgical patients were randomly divided into control group(group C,n=12) and penehyclidine hydrochloride group(group P,n=12).Penehyclidine hydrochloride(0.02 mg/kg) was intravenously injected at 30 min before CPB in group P,meanwhile 5 mL physiological saline was injected in group C.The concentration of TN... |
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| Keywords: | Penehyclidine hydrochloride Cardiopulmonary bypass Respiratory index P（A-a）DO2 TNF-α IL-6 |
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