急性有机磷农药中毒患者ICAM-1的检测及意义

目的探讨急性有机磷农药中毒（AOPP）患者血清细胞间粘附分子-1（ICAM-1）的水平变化及临床意义。方法采用ELISA法检测68例AOPP患者第1天、第3天、第5天和恢复期（12—14d）及64例正常健康体检者血清ICAM-1的水平变化。结果AOPP在第1天的ICAM-1含量最高，与正常对照组比较差异有统计学意义（P〈0．01）；第3天、第5天的ICAM-1仍持续较高水平，与正常对照组比较差异均有统计学意义（均P〈0．05），恢复期ICAM-1组和正常对照组比较差异无统计学意义（P〉0．05）；AOPP患者在住院5d内ICAM—1：轻度组与中度组比较差异有统计学意义（P〈0．05）；与重度组比较差异也有统计学意义（P〈0．01）；中度组与重度组比较差异有统计学意义（P〈0．01）。AOPP病情越重，血清ICAM-1水平越高。结论血清ICAM-1参与了AOPP的病理过程，且与中毒程度相关，具有统计学意义。

Changes of Level of Serum ICAM-1 and its Clinical Significance in Patients with Acute Organic Phosphorus Pesticide Poisoning

Objective To explore the changes of level of serum ICAM-1 and its clinical significance in patients with acute organic phosphorus pesticide （AOPP） poisoning. Methods Serum ICAM-1 was measured on the 1st day, 3rd,Sth day and on 12- 14 days in 68 patients with AOPP poisoning and 64 healthy individuals. Results Serum ICAM-1 level was the highest on the 1st day, and maintained the higher level on the 3rd,Sth day（P 〈 0.05 ） ,but was not statistical different on 12-14 days（ P 〉 0.05 ）, compared with control group. Within the first 5 days of the treatment, serum ICAM-1 level were dramatically different between slight group,moderate group and severe group （P 〈 0.05 ）. Serum ICAM-1 level was positively correlated with the severity of AOPP poisoning. Conclusion ICAM-1 was involved in the pathogenesis of AOPP poisoning, and assiociated with the course of AOPP poisoning.