N端脑钠肽前体检测在临床疾病诊断中的研究

目的 探讨血清N端脑钠肽前体在心脏功能衰竭、脑梗死及肾脏功能衰竭疾病的诊断以及治疗监测中的研究.方法 选择健康体检者30例作为正常对照组,同时选取经临床确诊的心功能衰竭患者101例、脑梗死患者95例及肾脏功能衰竭患者66例;采用罗氏全自动电化学发光免疫分析系统检测受检者血清N端脑钠肽前体浓度.结果 正常对照组、肾功能衰竭组、心功能衰竭组及脑梗死组血清N端脑钠肽前体的检测结果（（x）±s,pg/ml）分别为：55.41±25.63,15 110.08±22 951.45,5 082.35±9 546.15和1 960.06±2 653.07.正常对照组与临床三组间及临床三组之间结果经t检验分析,t值在-2.73-6.99之间,P均＜0.01,差异有统计学意义.结论 血清N端脑钠肽前体浓度水平不仅是评价和监测心功能状态的良好指标,同时对脑梗死及肾脏功能衰竭患者的诊断与治疗监测亦具有重要的临床意义.研究结果表明,即血清N端脑钠肽前体浓度水平在临床疾病的诊断中具有非常广泛的应用价值.

Investigation on Detection of Serum N-terminal Pro-brain Natriuretic Peptide in Diagnosis of Clinical Diseases

Objective To investigate the clinical significance of serum N-pro BNP in diagnosis and treatment surveillance ofcardiac failure,cerebral infarction and renal failure. Methods Serum N-pro BNP were detected with Roche Eleesys 2012 au-tomatic electrochemiluminescence immunoassay system in healthy subjects as normal control group, 101 patients with clinicaldiagnostic cardiac failure,95 ones with cerebral infarction and 66 ones with renal failure. Results The amounts of serum N-terminal pro-brain natriuretic peptide in healthy subjects, patients with renal failure, ones with cardiac failureand ones with cerebral infarction were 55.41±25.63,15 110.08±22 951.45,5 082.35±9 546.15 and 1 960.06± 2 653.07respectively. The statistical analysis between healthy group and any one among three clinical ones was carried out with resultof statistical difference,so was paired-comparisons among three clinical groups. The value of t test was between --2.73 and6.99 （P〈0.01）. Conclusion This study showed that serum N-pro BNP is a good indicator of estimation and surveillance ofheart function and has an important clinical significance of diagnosis and treatment surveillance in cerebral infarction and re-nal failure. The detection of concentration level of serum N-pro-BNP has very wide application value of clinical diagnosis.