2004～2008年我院头孢菌素类抗生素应用分析

目的：了解株洲一医院2004年1月～2008年8月头孢菌素类抗生素的临床应用情况，为临床合理应用提供依据。方法：采用限定日剂量（DDD）对该院头孢菌素类抗生素的用药金额、用药频度（DDDs）、限定日费用（DDDc）等进行统计分析。结果：5年来，医院头孢菌素类抗生素的用药金额、DDDs和DDDc呈逐年上升的趋势，而且其年度用药金额占医院药品总销售金额10．14％-13．62％、占抗感染药物销售金额35．57％～47．54％；第3代头孢菌素类抗生素用药金额最高（27．79％-43．70％）。头孢菌素类抗生素用药金额以头孢哌酮／舒巴坦居首位。第4代头孢菌素类抗生素增长幅度最快。2004—2008年该院头孢菌素类抗生素的用药金额、DDDs、DDDc的年均增长率分别为17．28％、5．07％、11．62％；第3代头孢菌素类抗生素的用药金额、DDDs均居首位，且年均增长率分别为24．86％、1．33％；头孢菌素类抗生素DDDs值前6位排序变化不大，以头孢氨苄、头孢氨苄，甲氧苄啶、头孢哌酮，舒巴坦、头孢克肟、头孢他美酯等的DDDs较高。结论：该院头孢菌素类抗生素使用基本合理，但应控制第3代头孢菌素类抗生素及β-内酰胺酶复合剂的使用。

Utilization of Cephalosporins in Our Hospital During 2004 - 2008

OBJECTIVE： To probe into the utilization of cephalosporins in the First Hospital of Zhuzhou from January 2004 to August 2008 so as to provide reference for clinical rational drug use. METHDOS： The utilization of cephalosporins was analyzed statistically in respect the consumption sum, DDDs and DDDe etc. RESULTS： During the 5 years, the consumption sum, DDDs and DDDc of eephalosporins increased year on year, with annual consumption sum representing 10.14% - 13.62% of the total drugs used in the hospital or 35.57% ~ 47.54% of the total anti - infectives. The consumption sum of the third generation cephalosporins took the lead, accounting for 27.79 % - 43.70 %. Sulbaetam ＋ Cefoperazone took the lead among all the eephalosporins. The consumption of the fourth generation eephalospofins increased most sharply during the 5 years, from 2004 to 2008, the annual incremental rates of cephalosporins in consumption sum, DDDs and DDDc were 17.28%, 5.07% and 11.62% respectively. The third generation cephalosporins took the lead in both consumption sum and DDDs, with annual incremental rates of 24.86 % and 1.33 % respectively. During the 5 years, the sequence of DDDs of the top 6 Cephalosporins had little change, leading the list were Cefalexin, Cefalexin - Trimethoprim, Sulbaetam- Cefoperazone, Cefixime and Globocef etc. CONCLUSION： The use of eephalosporins in our hospital was reasonable on the whole, but the use of the third generation of cephalosporins and their β - lactamase compound preparations should be kept under control.