尿白蛋白片段与心脑血管损伤的关系

为探讨尿白蛋白片段与心血管损伤的关系，用改进的免疫印迹法分析心血管损伤疾病患者尿白蛋白片段，尿样来自１１２例无并发症原发性高血压患者，另有４６例并发冠心病和３６例并发脑血管病的原发性高血压患者以及１０８例健康人。有心脑血管损伤性疾病的患者尿中可见异常尿白蛋白片段（４５ｋＤａ、３０ｋＤａ和２２ｋＤａ）。原发性高血压、并发冠心病和并发脑血管病患者尿白蛋白片段的阳性率分别为３２．３％、６０．８％和６６．７％。这些患者的尿白蛋白片段阳性率明显高于健康人（４．６０％，Ｐ〈０．０１），且合并心脑血管病的原发性高血压患者尿白蛋白片段的阳性率也明显高于单纯原发性高血压患者。尿白蛋白片段与微量白蛋白尿、甘油三酯和总胆固醇等指标呈正相关。提示尿白蛋白片段与心脑血管疾病明显相关，可作为一析的非创伤性检查心脑血管损伤的参考指标。

Correlation between Urinary Albumin Fragments and Cardiovascular Diseases

Aim To explore the relationship between the urinary albumin fragments(uAF) and cardiovascular damage. Methods The improved western blot was employed for analysis of uAF in urine of the patients with cardiovascular damagied disorders. Sample from 112 patients with non-diabetic primary hypertension, 46 coronary artery disease and 36 cerebrovascular disease as well as 108 healthy volunteers were examined. Results The anomalous fragments (45 kDa, 30 kDa, 22 kDa)are detected in the urine of patients with cardiovascular damagied disorders, the prevalences of uAF in hypertension, coronary artery disease, cerebrovascular disease and healthy volunteers were 32.33%, 60.87%, 66.67% and 5.00% respectively, the incidence of detection of uAF in these patients is significantly higher than that in healthy voluntees(P<0.01). uAF is related to MAU, TG and TC. Conclusions uAF and ardiovascular damage are significantly related, uAF can be used as a new reference indicator of non-injury for determining cardiovascular damage.