| 被动型Heymann肾炎大鼠外周血淋巴细胞诱生IL－2水平的动态观察 |
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| 引用本文： | 陈书芬,孙君江,阴东平,张建明.被动型Heymann肾炎大鼠外周血淋巴细胞诱生IL－2水平的动态观察[J].现代免疫学,1996(4). |
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| 作者姓名： | 陈书芬 孙君江 阴东平 张建明 |
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| 作者单位： | 南京医科大学附属南京第一医院肾内科，南京铁道医学院附属医院肾科，南京市第一医院中心实验室，南京铁道医学院病理教研室 |
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| 摘 要： | 为了检测被动型ｎｅｙｍａｎｎｇ肾炎（ＰＨＮ）大鼠细胞免疫状况，我们将抗肾小管刷状缘的抗体腹腔注射大鼠体内而建立了被动Ｈｅｙｍａｎｎ肾炎模型，在ＰＨＮ的最初２８ｄ，用ＭＴＴ比色法检测了７ｄ．１４ｄ、２８ｄ时外周血淋巴细胞诱生ＩＬ－２水平的变化，结果７ｄ时ＩＬ－２水平为２６．５２±１０．７２Ｕ／ｍｌ，与正常对照组３９．８０±９．４０Ｕ／ｍｌ相比显著差异（Ｐ＜０．０１），１４ｄ时ＩＬ－２水平为３０．６８±１１．７９Ｕ／ｍｌ（Ｐ＜Ｏ．０５），２８ｄ时ＩＬ－２水平为３２．７２±８．７２Ｕ／ｍｌ（Ｐ＜０．０５），提示ＰＨＮ大鼠存在免疫功能紊乱。
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| 关 键 词： | 被动型Heymann肾炎，白介素2 |
A Dynamic Observation on the interleukin-2 Levels induced by Peripheral Blood Lymphocytes in Passive Heymann Nephritis of Rats |
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| Chen Shufen,Sun Junjiang,Yin Dongping,Zhang Jianming.A Dynamic Observation on the interleukin-2 Levels induced by Peripheral Blood Lymphocytes in Passive Heymann Nephritis of Rats[J].Current Immunology,1996(4). |
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| Authors: | Chen Shufen Sun Junjiang Yin Dongping Zhang Jianming |
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| Abstract: | Passive Heymann Nephritis(PHN)of rat model was established by injection antiserum against proximal tubular brush border antigen to rats peritoneally,and the levels of interleukin-2 induced by peripheral blood lymphocytes were measured.Theresults showed that the IL-2 levels in PHN rats were lower than those of normalrats,suggesting that PHN rats might have somewhat dysfunctions in cellular immunity. |
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| Keywords: | Passive Heymann Nephritis IL-2 |
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