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Prognostic factors for fatal outcomes prior to receiving liver transplantation in patients with non-acetaminophen-related fulminant hepatic failure
Authors:Miyake Yasuhiro  Iwasaki Yoshiaki  Makino Yasuhiro  Kobashi Haruhiko  Takaguchi Kouichi  Ando Masaharu  Sakaguchi Kohsaku  Shiratori Yasushi
Affiliation:Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. miyakeyasuhiro@hotmail.com
Abstract:
BACKGROUND AND AIM: Many patients continue to die due to the rapid development of cerebral edema and/or multiple organ failure prior to receiving a liver transplantation. METHODS: We investigated the prognostic factors associated with 1-week fatal outcomes after the diagnosis of fulminant hepatic failure, which were associated with fatal outcomes prior to receiving liver transplantation, in 104 patients with non-acetaminophen-related fulminant hepatic failure. RESULTS: With a multivariate logistic regression analysis, age (>40 years), systemic inflammatory response syndrome (SIRS) and plasma prothrombin activities (40 years), cause of fulminant hepatic failure (viral hepatitis), plasma prothrombin activity (
Keywords:fulminant hepatic failure    liver transplantation    prognostic factor    protease inhibitor    systemic inflammatory response syndrome
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