冠心病患者冠脉病变严重程度的危险因素研究

目的 探讨影响或预测冠状动脉狭窄严重程度的相关因素.方法 收集海南省人民医院2008年1月至2010年4月行冠状动脉造影检查的患者95例.对冠心病患者可能的危险因素或预测指标如年龄、性别、高血压、糖尿病、吸烟、血脂水平、左房左室大小、高敏C反应蛋白等与冠脉病变程度进行相关性分析.冠脉病变程度由病变血管支数及Gensini积分表示.结果 冠脉病变支数越多,Gensini积分越高.冠心病患者冠脉狭窄严重程度与2型糖尿病及高敏C反应蛋白水平呈正相关,相反,心肌桥患者冠脉病变程度较轻.结论 2型糖尿病及高水平的高敏C反应蛋白对冠心病患者冠脉病变程度有独立的预测价值,心肌桥与冠脉病变负性相关.

Risk factors associated with severity of coronary artery stenosis

Objective To explore the correlation between traditional risk factors of coronary heart disease and the severity of coronary artery stenosis.Methods 95 patients admitted to our hospital from January 2008 to April 2010 who underwent angiography were enrolled.Correlation between common risk factors of coronary artery disease（CAD） such as age,gender,hypertension,diabetes,smoke,blood lipid,the size of left atrium and ventricle,high sensitive C reactive protein（hs-CRP） and the severity of coronary artery stenosis were evaluated by logistic regression analysis.CAD severity was assessed by the number of arteries involved and the Gensini score.Results The number of arteries involved was correlated with the Gensini score.The extent and severity of CAD were positively correlated with diabetes and hs-CRP,while negatively correlated with myocardial bridge.Conclusion Diabetes and hs-CRP were independent risk factor for the severity of CAD,however,coronary artery with myocardial bridge was negatively correlated with severe stenosis.