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Tricyclic antidepressive drugs and dopamine-sensitive adenylate cyclase from rat brain striamtum |
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| Authors: | Manfred E. Karobath |
| Affiliation: | Department of Experimental Psychiatry, Psychiatrische Universitätsklinik, Universität Wien, Vienna, Austria |
| Abstract: | Tricyclic antidepressant drugs were examined as inhibitors of dopamine-sensitive adenylate cyclase in a cell-free homogenate of rat brain striatum. Amitriptyline (Ki 0.17 μM) and doxepin (Ki 0.24 μM) were found to be potent inhibitors of dopamine-sensitive adenylate cyclase, chlorimipramine (Ki 0.59 μM) and nortriptyline (Ki 0.50 μM) were moderate inhibitors and imipramine, desmethylimipramine, protriptyline melitracene were weak inhibitors with Ki values higher than 1 μM. |
| Keywords: | Adenylate cyclase Striatum, rat Antidepressant drugs Amitriptyline Dopamine receptor Doxepin |
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