宜昌市职业人群非酒精性脂肪性肝病流行病学调查及其与代谢综合征相关性研究

目的：调查研究宜昌市职业人群中非酒精性脂肪肝（NAFLD）患病率及其与代谢综合征（MS）的关系，对本市职业人群NAFLD患病规律进行分析。方法抽样调查宜昌市城区15个单位职业人群共6450人（男3284人，女3166人），年龄20～70岁，对其进行体格和肝区超声检查，并抽取空腹血进行葡萄糖、三酰甘油、高密度脂蛋白胆固醇、尿酸、CRP等检测，对结果进行统计分析。结果宜昌市职业人群NAFLD的患病率为21．71％，男性为28．68％，女性为14．47％（P＜0．01）。60岁以前各年龄段男性患病率明显高于女性，女性患病率与年龄呈正相关，60岁后达31．31％。NAFLD组中，MS相关组分中患病率最高的为肥胖（69．98％）、高TG血症（61．10％）。结论宜昌市职业人群中60以下男性、60岁以上女性为NAFLD患病高风险人群，该群体应作为定期监测、预防和干预的重点。MS人群中NAFLD患病率显著增高，其最重要相关因素为肥胖、高TG血症。

Epidemiology investigation of nonalcoholic fatty liver disease in Yichang professional crowd and its correlation with the metabolic syndrome

Objective To study the prevalence rate of nonalcoholic fatty liver disease (NAFLD)and its correlation with the metabolic syndrome among professional crowd in Yichang city ,and analyze the characteristic of prevalence of NAFLD .Methods Physical check‐up and liver ultrasonography were done and fasting blood GLU ,TG ,HDL‐C ,UA ,CRP were measured for sampling survey professional people in Yichang city .We sampled 6 450 people in 15 company ,including 3 284 men ,3 166 women(20 to 70 years old) ,the results were analyzed .Results The NAFLD prevalence rate of Yichang professional crowd was 21 .71% ,28 .68% in male and 14 .47% in female respectively(P<0 .01) .The prevalence rate in male was higher than that of female before 60 years old . NAFLD prevalence rate in women showed a trend of increasing along with the age growth ,the incidence rate come up to 31 .31%when women were over 60 years old .The highest prevalence rate of MS related components in NAFLD group were obesity (69 .98% )、high blood TG level(61 .10% ) .Conclusion Male before 60 years old and female over 60 years old of Yichang profes‐sional crowd belong to NAFLD high‐risk groups ,the group should be focused on as regular monitoring ,prevention and interven‐tion .NAFLD prevalence rate significantly increased in people with MS .The most important factors of suffering from NAFLD are o‐besity ,high blood TG level .