| 生物制剂在炎症性肠病治疗中的应用与展望 |
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| 引用本文： | 张涛,苏晓兰,毛心勇,刘倩,吴宝麒,宋耿青,魏玮.生物制剂在炎症性肠病治疗中的应用与展望[J].转化医学杂志,2021,10(2):112-115. |
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| 作者姓名： | 张涛 苏晓兰 毛心勇 刘倩 吴宝麒 宋耿青 魏玮 |
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| 作者单位： | 中国中医科学院望京医院脾胃病科功能性胃肠病中医诊治北京市重点实验室;北京中医药大学;Department of Gastroenterology and Hepatology, Case Western Reserve University/MetroHealth Medical Center, Cleveland, OH |
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| 基金项目： | 国家自然科学基金面上项目（81973638）；国家重大疑难疾病溃疡性结肠炎（久痢）中西医临床协作试点项目 |
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| 摘 要： | 炎症性肠病（Inflammatory Bowel Disease，IBD）传统治疗药物存在自身的局限性，生物制剂的应用拓宽了IBD的治疗途径。目前，7种生物制剂已经被美国食品药品监督管理局（Food and Drug Administration，FDA）正式批准用于IBD的治疗,本文就已被批准的生物制剂在临床研究中治疗IBD的疗效、安全性以及目前面临的临床问题进行系统梳理，希望能帮助医学同道对生物制剂治疗IBD的风险和获益有一整体把握。
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| 关 键 词： | 炎症性肠病 生物制剂 应用与展望 |
Application and Prospect of Biological Agents in the Treatment of Inflammatory Bowel Disease |
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| Authors: | ZHANG Tao SU Xiaolan MAO Xinyong LIU Qian WU Baoqi SONG Gengqing WEI Wei |
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| Institution: | Department of Spleen and Gastroenterology, Wangjing Hospital, China Academy of Chinese Medical Sciences,Beijing Key Laboratory of TCM Diagnosis and Treatment of Functional Gastroenterology, Beijing 100102, China;;Beijing University of Traditional Chinese Medicine, Beijing 100029, China;Department of Gastroenterologyand Hepatology, Case Western Reserve University/MetroHealth Medical Center, Cleveland, OH |
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| Abstract: | raditional treatments for inflammatory bowel disease have their own limitations, and the application of biological agents has broadened the treatment of IBD. At present, 7 biological agents have been officially approved by the Food and Drug Administration (FDA) for the treatment of IBD. This article is about the efficacy, safety of the approved biological agents in the clinical study of IBD. The current clinical problems are systematically sorted out, hoping to help readers have an overall grasp of the risks and benefits of biological agents in the treatment of IBD. |
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| Keywords: | Inflammatory bowel disease (IBD) Biological agents Application and prospect |
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