炎性小体在炎症性疾病中的研究进展

炎性小体与多种炎症性疾病的发生有关.作为固有免疫系统重要的受体和传感分子,炎性小体能对许多具有感染性的微生物及分子作出应答,从而调控Caspase-1的激活并诱导炎症反应的发生.最新的研究通过诱导不同炎性小体的激活,极大地促进了我们对炎性小体和炎症性疾病之间内在分子机制的认识.此外,越来越多动物模型的证据证明,炎性小体...

Research progress of Inflammasomes in Inflammatory Diseases

Inflammasomes have been found to be related to the progression of inflammatory diseases. Acting as the significant receptor and sensing element of the innate immune system, inflammasomes could be activated by infective microorganisms and substances, resulting in Caspase-1 activation and inflammatory responses. Recent studies have greatly contributed to our understanding of the mechanisms underlying between inflammasomes and inflammatory diseases by the activation of different inflammasomes. In addition, incresing evidence from animal models supports that inflammasomes are involved in the initiation and progression of many diseases, and these diseases have a dramatic impact on public health. Finally, recent studies have pointed out targeting inflammasomes as a potential therapeutic method in inflammatory diseases. Based on this, we will provide a review of these three aspects of inflammasomes in inflammatory diseases.