玻璃酸钠联合rhEGF滴眼液治疗白内障术后干眼疗效的Meta分析

目的:运用Meta分析方法系统评价近5a玻璃酸钠联合重组人表皮生长因子(rhEGF)滴眼液治疗白内障术后干眼的疗效。方法:计算机检索2015-01/2020-05中国知网数据库、万方数据库、重庆维普中文科技期刊全文数据库、中国生物医学文献数据库(CBM)、Cochrane Library、PudMed、MEDLINE等数据库关于采用玻璃酸钠联合rhEGF滴眼液治疗白内障术后干眼的的临床对照研究相关文献,使用Rev-man 5.3统计软件进行Meta分析和统计处理。结果:共纳入14项随机对照研究,患眼1529例。其中14项研究在治疗结束后进行了角膜荧光素染色(FL)评分,结果显示差异有统计学意义MD=-0.86,95%CI(-1.07~-0.66),P<0.00001];14项研究在治疗结束后进行了泪膜破裂时间(BUT)测定,结果显示差异有统计学意义MD=2.33,95%CI(1.64~3.03),P<0.00001];12项研究在治疗结束后进行了泪液分泌试验(SⅠt)测定,结果显示差异无统计学意义MD=0.49,95%CI(-0.52~1.50),P=0.34];12项研究在治疗结束后进行了总体有效率计算,结果显示差异有统计学意义OR=4.88,95%CI(3.34~7.14),P<0.00001];4项研究在治疗结束后进行了干眼症状评分测定,结果显示差异有统计学意义MD=-1.09,95%CI(-1.58~-0.61),P<0.00001]。结论:玻璃酸钠联合rhEGF滴眼液治疗白内障术后干眼能显著提高角膜修复能力和BUT,在治疗白内障术后干眼总体疗效上更具优势。

Meta-analysis of the efficacy of sodium hyaluronate eye drops combined with rhEGF eye drops in the treatment of dry eye after cataract surgery

AIM: To systematically evaluate the efficacy of sodium hyaluronate combined with recombinant human epidermal growth factor(rhEGF)eye drops in the treatment of dry eye after cataract surgery in recent 5a by Meta-analysis.METHODS: The databases of CNKI, WanFang, Chongqing VIP, CBM, Cochrane Library, Pudmed and MEDLINE from January 2015 to May 2020 were searched. Meta analysis and statistical analysis were performed with Revman 5.3 software on the clinical control study of sodium hyaluronate eye drops combined with rhEGF eye drops in the treatment of dry eye after cataract surgery.RESULTS: A total of 14 randomized controlled trials involving 1 529 eyes were included. Among them, 14 studies conducted corneal fluorescein staining(FL)score after the end of treatment, the results showed that the difference was statistically significant MD= -0.86, 95%CI(-1.07 to -0.66), P<0.00001]; 14 studies conducted tear film break-up time(BUT)measurement after the end of treatment, the results showed that the difference was statistically significant MD=2.33, 95%CI(1.64, 3.03), P<0.00001], 95%CI(1.76 to 2.15), P<0.00001]; tear secretion test(S I t)was measured in 12 studies after treatment, and the results showed that there was no significant difference MD=0.49, 95%Cl(-0.52, 1.50), P=0.34]; the overall effective rate was calculated in 12 studies after treatment, and the results showed that the difference was statistically significant OR=4.88, 95%Cl(3.34, 1.50), P=0.34]. The results showed that the difference was statistically significant MD= -1.09, 95%Cl(-1.58, -0.61), P<0.00001].CONCLUSION: Sodium hyaluronate combined with rhEGF eye drops in the treatment of dry eye after cataract surgery can significantly improve the corneal repair ability and tear film BUT, which has more advantages in the overall efficacy of the treatment of dry eye after cataract surgery.