基于WNT16预防骨质疏松非椎体骨折的研究进展

随着我国老龄化程度加深,骨质疏松发病率持续升高,已经严重威胁我国国民健康。骨折作为骨质疏松最严重的并发症,是骨质疏松患者死亡的主要原因。近年来,关于骨质疏松骨折的研究有很多,但偏重于骨质疏松椎体骨折,而骨质疏松非椎体骨折的研究较少。目前,市场上预防骨质疏松的药物也往往针对椎体骨折,而骨质疏松非椎体骨折的可用药物较少。WNT信号通路在预防骨质疏松骨折方面的研究较多,WNT16作为WNT家族中新成员,是调控骨皮质的关键因子,骨质疏松非椎体骨折的关键原因在于骨皮质变薄,因此,WNT16可能是预防非椎体骨折的潜在靶标。本文主要通过总结近期关于WNT16在骨质疏松骨折上的研究,探讨WNT16在骨质疏松非椎体骨折的预防上所起的作用,为临床预防骨质疏松非椎体骨折提供参考,以及为骨质疏松非椎体骨折药物开发提供新思路。

Research progress in the prevention of osteoporotic non-vertebral fractures based on wnt16

With the deepening of aging in China, the incidence rate of osteoporosis has been increasing, which has seriously threatened the health of our citizens. As the most serious complication of osteoporosis, fracture is the main cause of death in patients with osteoporosis. In recent years, there are many researches on osteoporotic fractures, but they focus on osteoporotic vertebral fractures, and few studies on osteoporotic non vertebral fractures. At present, the drugs to prevent osteoporosis in the market are often aimed at vertebral fracture, while the drugs for osteoporosis non vertebral fracture are less. As a new member of Wnt family, wnt16 is a key factor in regulating the bone cortex. Therefore, wnt16 may be a potential target for the prevention of non vertebral fractures. This article mainly summarizes the recent research on wnt16 in osteoporotic fractures, and discusses the role of wnt16 in the prevention of osteoporotic non vertebral fractures, in order to provide reference for clinical prevention of osteoporotic non vertebral fractures, and provide new ideas for the development of drugs for osteoporosis non vertebral fractures.