基于网络药理学探讨桑黄治疗肝炎的作用机制

目的 运用网络药理学方法研究桑黄治疗肝炎的有效成分及作用靶点,为深入探索其药理作用机制提供依据.方法 本研究采用TCMSP平台中的CancerHSP软件检索桑黄的化学成分、作用靶点,通过Uniprot数据库及GendCards数据库分别检索各化学成分和肝炎对应的靶基因,找出关键基因;采用Cytoscape 3.7.2软...

Mechanism of Phellinus igniarius on hepatitis based on network pharmacology

Objective To study the active components and action targets of Phellinus igniarius in the treatment of hepatitis by network pharmacology.So as to provide a basis for further exploration of its pharmacological action mechanism.Methods This study used the CancerHSP in the TCMSP platform to retrieve the chemical constituents and action targets of Phellinus igniarius.Cytoscape 3.7.2 was used to make the network map of Phellinus igniarius-Hepatitis-target.Target protein-protein interaction(PPI)network was constructed by using String database.ClueGo software was used to perform functional enrichment analysis and KEGG pathway analysis of key targets.Results A total of 9 compounds were retrieved and 3 compounds,27 targets and 30 genes were screened out.There are 22 key genes associated with hepatitis,including MAOB,XDH,ALDH2,SMAD3,ALDH3A1 and CYP2A6.Histidine metabolism,Tyrosine metabolism and other 7 pathways play a role.Conclusion This study preliminarily verified the therapeutic target and pathway of Phellinus igniarius in the treatment of hepatitis,and laid a foundation for further revealing its liver protection mechanism.