慢性乙型肝炎中医证型与拉米夫定抗病毒疗效及耐药发生率的关系研究

目的：观察慢性乙型肝炎中医证型与拉米夫定抗病毒疗效及耐药发生情况的关系。方法：选择符合抗病毒治疗的慢性乙型肝炎患者150例，按中医辨证分湿热中阻型、肝郁脾虚型、肝肾阴虚型、脾肾阳虚型、瘀血阻络型。各型患者分别服用拉米夫定抗病毒治疗3年，观察拉米夫定对不同中医证型患者的HBV DNA的转阴率以及耐药发生情况与中医证型之间的关系。结果：湿热中阻型患者HBV DNA的转阴率最高，而耐药发生率最低，与其他证型比较差异有统计学意义。结论：慢性乙型肝炎患者拉米夫定抗病毒的疗效及耐药发生率与中医证型相关。

Relationship between traditional Chinese medicine syndrome of chronic hepatitis B and anti-viral curative effect and drug resistance rate by lamivudine

Objective： To study the relationship between the traditional chinese medicine （ TCM ） syndrome of chronic hepatitis B （ CHB） and the anti-viral curative effect and drug resistance rate by lamivudine.Methods： One hundred and fifty patients of CHB were divided into five groups by TCM syndrome , which were damp-heat blocking the middle group （ A） , de-pressed liver and deficient spleen group （ B） , Yin deficiency of liver and kidney group （ C） , Yang deficiency of spleen and kid-ney group （ D） and blood stasis blocking collaterals group （ E） .The patients orally took lamivudine for three years and the rela-tionship between the rate of the negativity rate and HBV DNA of drug resistance of different TCM syndrome were closely investiga -ted.Results： The highest negativity rate of HBV DNA and the lowest drug resistance rate were in damp -heat blocking the middle group （A）, comparison with other TCM syndrome with statistical significance.Conclusion： The anti-viral curative effect and drug resistance rate of lamivudine treatment in patients with CHB is closely correlated with TCM syndrome .