小剂量多索茶碱持续泵入治疗慢性阻塞性肺疾病的疗效观察

目的:观察多索茶碱与氨茶碱及多索茶碱不同给药方式治疗慢性阻塞性肺疾病的临床疗效.方法:将180例慢性阻塞性肺疾病患者随机分为3组:多索茶碱持续泵入治疗组(A组)、多索茶碱静脉滴注治疗组(B组)和氨茶碱对照组(C组),观察3组治疗的临床疗效、不良反应等.结果:多索茶碱临床总有效率明显高于对照组,且持续泵入组不良反应发生率最低,3组之间差异有统计学意义(P＜0.05).结论:多索茶碱是一种安全有效的治疗慢性阻塞性肺疾病的药物,且使用持续微量泵泵入可更好地维持药物浓度,减少不良反应,值得临床推广运用.

Effect of Consistent Pumping of low Dose Doxofylline Treatment on Chronic Obstructive Pulmonary Disease

Objective:To observe the clinical effect of doxofylline and aminophyline treatment on chronic obstructive pulmonary disease.Methods:180 cases of COPD patients were randomly divided into consistent pumping of lose dose doxofylline treatment group(A group) and drips of doxofylline treatment group(B group) and aminophyline control group(Cgroup).Observe the clinical effect and non-performing reaction of 3 groups.Result:The total effective rate of doxofylline treatment group were higher than aminophyline control group,non-performing reaction rate of consistent pumping of lose dose doxofylline was lowest,The difference all these three groups was Statistically significant(P<0.05).Conclusion:It could be concluded that doxofylline was safe and effect on treating chronic obstructive pulmonary disease.Using the minim pump to continue microdosis venous pump can keep the density of drug better and reduce harmful reaction and it is worthy of clinical popularizing and application.