缺氧诱导因子-1α在膀胱移行细胞癌组织中的表达及其临床意义

目的 检测膀胱移行细胞癌（BTCC）组织中HIF-1α的表达情况,初步探讨HIF-1α在膀胱移行细胞癌中表达的临床意义.方法 应用免疫组织化学检测膀胱移行细胞癌组织中HIF-1 α的蛋白表达,并分析其表达与肿瘤临床分期、病理分级及复发的关系.结果 12例正常膀胱组织未发现HIF-1α阳性表达,57例膀胱移行细胞癌组织中有30例HIF-1 α表达阳性,阳性表达率占52.63%.其表达与肿瘤的病理分级无关,但与肿瘤的临床分期及复发明显相关.结论 在膀胱移行细胞癌中,HIF-1α的表达均明显上调,HIF-1α在膀胱移行上皮细胞癌的侵袭等生物学过程中具有重要的作用,HIF-1α可能可以用于临床监控膀胱肿瘤的进展.

Expression of HIF-1alpha and potiented clinical implications in human bladder transitional cell carcinoma

[Objective] The aim of this study was to investigate the clinicopathological significance of HIF-1alpha expression in bladder transitional cell carcinoma. [Methods] HIF-1alpha protein expression was determined using immunohistochemistry. The relationship between HIF-1alpha expression and various clinicopathological parameters including pathological grade and clinical stage was analyzed. [Results] Over-expression of HIF-1alpha was frequently (30 of 57 cases, 52.63%) detected in bladder transitional cell carcinoma tissues, whereas no HIF-1alpha expressions in the 12 normal bladder tissues. HIF-1alpha expression was significantly associated with invasive bladder cancer, but not with increased pathological grade. [Conclusion] HIF-1alpha is frequently expressed in bladder transitional cell carcinoma, HIF-1alpha may play a critical role in the invasion of bladder carcinoma and can be used to estimate the progression of bladder carcinoma for clinical work.