| 长效避孕皮下埋植剂体外缓释行为研究 |
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| 引用本文： | 刘伟,张德.长效避孕皮下埋植剂体外缓释行为研究[J].生物医学工程研究,1997(2). |
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| 作者姓名： | 刘伟 张德 |
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| 作者单位： | 山东省医疗器械研究所 济南250013 |
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| 摘 要： | 本文对以加成型硅橡胶为基质的左旋18—甲基炔诺酮长效避孕埋植剂的体外释放行为及对可能影响其释放量的诸因素,进行了观察与研究,结果表明:此长效避孕皮下埋植剂的体外释药行为,符合零级释药动力学规律。释药量受控释膜厚度,控释膜交联密度及释药面积的影响。体外释放药物曲线无明显爆破峰。
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| 关 键 词： | 埋植剂 左旋18—甲基炔诺酮(LNG) 体外释放速率 |
THE STUDY FOR THE DRUG RELEASING BEHAVIOR IN VITRO OF THE LONG CONTRACEPTIVE SUBCUTANEOUS IMPLANTS |
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| Liu Wei Zhang De.THE STUDY FOR THE DRUG RELEASING BEHAVIOR IN VITRO OF THE LONG CONTRACEPTIVE SUBCUTANEOUS IMPLANTS[J].Journal Of Blomedical Englneerlng Research,1997(2). |
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| Authors: | Liu Wei Zhang De |
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| Abstract: | The drug releasing behavior in vitro of the long contraceptive subcutaneous implant(LNG)was studied.The results showed that the releasing behavior in vitro conforms to the zero progression kinetic.The releasing amount for LNG was influenced by the thickness of the covering membrane,the crosslink density of the covering membrane, the area of releasing drug and the releasing medium.There wasn't evident blast peak on the curve of LNG releasing in vitro. |
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| Keywords: | Implant LNG Releasing rate in vitro |
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