A Double Pituitary Adenoma Presenting as a Prolactin-secreting Tumor with Partial Response to Medical Therapy. Case report |
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| Authors: | Claire I. Coiré Harley S. Smyth Dominic Rosso Eva Horvath Kalman Kovacs |
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| Affiliation: | (1) Department of Laboratory Medicine, Trillium Health Centre, Mississauga, ON, Canada;(2) Department of Neurosurgery, Trillium Health Centre, Mississauga, ON, Canada;(3) Department of Diagnostic Imaging, Trillium Health Centre, Mississauga, ON, Canada;(4) Department of Laboratory Medicine and Pathology, St. Michael’s Hospital, Toronto, ON, Canada;(5) Department of Pathology, Trillium Health Centre, 100 Queensway West, Mississauga, ON, L5B 1B8, Canada |
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| Abstract: | Double pituitary adenomas are difficult to recognize pre-operatively as only a single mass may be appreciated on imaging. We present herein a giant prolactin-secreting pituitary adenoma in a middle-aged man that had responded partially to dopamine agonist therapy. The excised specimen demonstrated a double adenoma. The prolactin-producing one displayed the expected morphological changes resulting from medical therapy, while the other, a gonadotroph adenoma, did not. The failure of tumor shrinkage can be attributed to the presence of a double adenoma, a previously unreported cause of failure of medical therapy in prolactinoma. |
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