PVP联合PKP结合药物治疗多节段骨质疏松性椎体压缩性骨折

目的 探讨椎体成形术（PVP）联合经皮椎体后凸成形术（PKP）治疗多节段老年骨质疏松性椎体压缩性骨折（OVCF）的疗效。方法 30例（108椎）OVCF患者行PVP+PKP术，术后给予鲑鱼降钙素、活性维生素D和钙剂治疗（治疗组）。20例（62椎）患者给予卧床休息3月，鲑鱼降钙素、活性维生素D和钙剂治疗（对照组）。两组患者分别于0w、24w和48w测股骨颈和胸腰椎骨密度。应用视觉模拟疼痛评分（VAS）对患者疼痛进行评价。结果 术后0周、24周和48周，两组患者股骨颈和胸腰椎多节段胸腰椎骨密度值，差异无统计学意义。术前、术后0w、24w和48w治疗组患者VAS评分明显降低，较对照组患者VAS评分具有统计学意义（P＜0.05）。结论 应用PVP联合PKP治疗多节段（OVCF）能有效缓解疼痛，是一种简单、安全有效的方法。

Effect of PKP and PVP combined with drug therapy on the treatment of multi-segmental osteoporotic vertebral compression fractures

Objective To explore the clinical effect of PVP and PKP on the treatment of multi-segmental osteoporotic vertebral compression fractures (OVCF) in elderly patients. Methods In treatment group, 30 OVCF patients (108 vertebrae) were treated by PVP and PKP. Salmon calcitonin, active vitamin D, and calcium were given after the operation. In control group, 20 patients (62 vertebrae) were treated with the same drugs without operation, resting in bed for 3 months instead. Bone mineral density of the femoral neck and the lumbar vertebrae was measured at the 0th, 24th, and 48th week, respectively. VAS was used to evaluate the pain of the patients. Results At the 0th, 24th, and 48th week after operation, bone mineral density of the femoral neck and the lumbar vertebrae between both groups had no statistical significance. But the VAS score decreased obviously in treatment group compared with that in the control group (P<0.05). Conclusion PVP and PKP can reduce the pain of patients with multi-segmental OVCF, which is simple, safe, and efficient.