胃蛋白酶原对儿童幽门螺杆菌相关胃炎诊断价值的研究

目的探讨胃蛋白酶原(PG)与幽门螺杆菌(HP)相关胃炎的关系及其诊断价值。方法对82例以上消化道症状就诊儿童进行PG检测,与胃镜结果对比,通过受试者工作特征曲线对PG诊断价值进行评价。结果 HP阳性组PGⅠ、PGⅡ水平明显升高,PGⅠ/PGⅡ降低。PGⅡ≥9.01μg/L的检出灵敏度和特异度分别为96.7%和75%。结论 PG水平与胃炎患儿HP感染状态密切相关。PGⅡ≥9.01μg/L可以作为辅助诊断儿童幽门螺杆菌相关胃炎的非侵入性指标。

Diagnostic Value of Pepsinogen Test in Children with Hpylori-related Gastritis

Objective To study the correlation between pepsinogen（PG）and H.pylori -related gastritis,and evaluate the diagnostic value of the test. Methods 82 children with upper gastrointestinal symptoms were analyzed. PG was detected,and were validated against the results from endoscopy and biopsies. Receiver operating characteristic curve（ROC）was plotted to quantify the accuracy. Results Hpylori-related non-atrophic chronic gastritis presented significantly higher levels of PG Ⅰ, PG Ⅱ and lower level of PG I/PG Ⅱ than negative ones. The sensitivity and specificity of PG Ⅱ≥ 9.01 μg/L were 96.7% and 75%. Conclusion Pepsinogen level is closely correlated with Hpylori infection. PG Ⅱ ≥9.01 μg/L could be a useful non-invasive panel for the assessment of H. pylori-related gastritis in childhood.