| 头孢噻肟成钠盐的工艺研究 |
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| 引用本文： | 卢娥辉, 郑熙展. 头孢噻肟成钠盐的工艺研究[J]. 中国现代应用药学, 2006, (2): 117-120. |
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| 作者姓名： | 卢娥辉 郑熙展 |
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| 作者单位： | 1. 汕头金石制药总厂,广东,汕头,515041
2. 汕头金石粉针剂有限公司,广东,汕头,515041 |
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| 摘 要： | 目的优选头孢噻肟成钠盐的工艺。方法以头孢噻肟酸为原料,采用正交试验法确定头孢噻肟成钠盐的最佳反应温度、成钠剂、有机溶媒;再以确定的工艺条件作重复试验,并将生成样品进行加速稳定性试验。结果头孢噻肟钠收率达93%(以头孢噻肟酸计),成品质量稳定且符合中国药典2000年版二部标准规定。结论本小试工艺合理,适合于进一步扩大中试生产。
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| 关 键 词： | 头孢噻肟钠 正交试验法 成钠盐工艺 重复试验 |
| 文章编号： | 1007-7693（2006）02-0117-04 |
| 收稿时间： | 2004-09-02 |
| 修稿时间： | 2004-09-02 |
The studies on the technics of cefotaxime formed sodium salt |
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| LU E-hui, ZHENG Xi-zhan. The studies on the technics of cefotaxime formed sodium salt[J]. Chinese Journal of Modern Applied Pharmacy, 2006, (2): 117-120. |
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| Authors: | LU E-hui ZHENG Xi-zhan |
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| Affiliation: | Shantou Jinshi General Pharmaceutical Factory , Shantou 515041, China;2. Shantou Jinshi Sterilize Powder for Injection Co. , Ltd ,Shantou 515041, China |
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| Abstract: | OBJECTIVE To choose the optimum technics of cefotaxime formed sodium salt.METHODS The optimum reactive temperature,sodium donor,organic solvent of cefotaxime formed sodium salt in technics was confirmed by orthogonal test method with cefotaxime as raw material;The repeating test continued according as certain technics condition,and the created sample carried through accelerate test.RESULTS The yield of cefotaxime sodium obtained 93%.(accounted with cefotaxime),and the product quality accorded with the standard of CP edition 2000.CONCLUSION This diminutive test technics is rationalized,adapt to enlarge medium test production. |
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| Keywords: | cefotaxime sodium orthogonal test method formed sodium salt technics repeating test |
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