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| Risk factors for Barrett＇s oesophagus and oesophageal adenocarcinoma： Results from the FINBAR study | |
| 引用本文： | Anderson LA,Watson RG,Murphy SJ,Johnston BT,Comber H,Mc Guigan J,Reynolds JV,Murray LJ. Risk factors for Barrett＇s oesophagus and oesophageal adenocarcinoma： Results from the FINBAR study[J]. World journal of gastroenterology : WJG, 2007, 13(10): 1585-1594. DOI: 10.3748/wjg.v13.i10.1585 |
| 作者姓名： | Anderson LA Watson RG Murphy SJ Johnston BT Comber H Mc Guigan J Reynolds JV Murray LJ |
| 作者单位： | Centre for Clinical and Population Sciences Queen's University,Belfast,Northern Ireland,Royal Group of Hospitals,Belfast,Northern Ireland,Centre for Clinical and Population Sciences,Queen's University,Belfast,Northern Ireland,Royal Group of Hospitals,Belfast,Northern Ireland,National Cancer Registry,Cork,Ireland,Royal Group of Hospitals,Belfast,Northern Ireland,St.James's Hospital,Dublin,Ireland,Centre for Clinical and Population Sciences,Queen's University,Belfast,Northern Ireland |
| 基金项目： | Supported by an Ireland-Northern Ireland Co-operation ResearchProject Grant sponsored by the Northern Ireland Research & Development Office,and the Health Research Board,Irel and.The Ulster Cancer Foundation also funded a PhD student and Post-doctoral fellow to work within the FINBAR study |
| 摘 要： | AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. |
| 关 键 词： | 巴雷特氏食管 食管腺癌 风险因子 FINBAR研究 抽烟 癌前病变 |
| 收稿时间： | 2006-09-11 |
Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study |
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| Anderson Lesley A,Watson R G Peter,Murphy Seamus J,Johnston Brian T,Comber Harry,Mc Guigan Jim,Reynolds John V,Murray Liam J. Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study[J]. World journal of gastroenterology : WJG, 2007, 13(10): 1585-1594. DOI: 10.3748/wjg.v13.i10.1585 | |
| Authors: | Anderson Lesley A Watson R G Peter Murphy Seamus J Johnston Brian T Comber Harry Mc Guigan Jim Reynolds John V Murray Liam J |
| Affiliation: | 1. Centre for Clinical and Population Sciences, Queen's University, Belfast, Northern Ireland 2. Royal Group of Hospitals,Belfast,Northern Inreland 3. National Cancer Registry,Cork,Ireland 4. St.James's Hospital,Dublin,Ireland |
| Abstract: | AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. |
| Keywords: | Barrett's oesophagus Oesophageal adenocarcinoma Smoking Gastro-oesophageal reflux Body mass index Diet Case-control |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |