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| 替比夫定治疗慢性乙型肝炎疗效的系统评价 | |
| 引用本文： | 杨声坪,李婧媛,张鹏,袁金秋,刘雅莉. 替比夫定治疗慢性乙型肝炎疗效的系统评价[J]. 世界华人消化杂志, 2011, 0(26) |
| 作者姓名： | 杨声坪 李婧媛 张鹏 袁金秋 刘雅莉 |
| 作者单位： | 兰州大学循证医学中心兰州大学基础医学院;兰州大学第一临床医学院;平凉市人民医院; |
| 摘 要： | 目的:系统评价替比夫定(LDT)治疗慢性乙型肝炎(CHB)的治疗效果.方法:应用Cochrane系统评价方法计算机检索Cochrane Library(2009年第3期)、PubMed(1966-2009.9)、EMBASE(1974-2009.9)、中国生物医学数据库(CBM,1978-2009.9)、中国期刊全文数据库(CNKI,1979-2009.9)和维普数据库(VIP,1989-2009.9),同时在临床试验注册网站及Google搜索引擎进行检索,并追查纳入研究参考文献,收集以LDT治疗CHB的所有随机对照试验(RCT)和交叉试验.根据Cochrane协作网推荐的风险评估工具进行风险偏倚评估,用RevMan5.0软件进行统计学分析.结果:最终纳入10个RCTs,共4037例患者.7篇LDT对比拉米夫定(LAM)的研究结果显示,对于HBeAg阳性患者,LDT组较LAM组更有效提高血清HBVDNA检测不到率(RR=1.50,95%CI:1.38-1.64)、ALT复常率(RR=1.10,95%CI:1.05-1.16)、HBeAg转阴率(RR=1.23,95%CI:1.08-1.40)和HBeAg血清转... |
| 关 键 词： | 替比夫定 慢性乙型肝炎 系统评价 |
Efficacy of telbivudine for chronic hepatitis B:a systematic review |
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| Sheng-Ping Yang,Jing-Yuan Li,Peng Zhang,Jin-Qiu Yuan,Ya-Li Liu,Center for Evidence-Based Medicine,School of Basic Medical Sciences,Lanzhou University,Lanzhou ,Gansu Province,China Sheng-Ping Yang,the First Clinical Medical College of Lanzhou University,China Jing-Yuan Li,Pingliang People's Hospital,Pingliang ,China. Efficacy of telbivudine for chronic hepatitis B:a systematic review[J]. World Chinese Journal of Digestology, 2011, 0(26) | |
| Authors: | Sheng-Ping Yang Jing-Yuan Li Peng Zhang Jin-Qiu Yuan Ya-Li Liu Center for Evidence-Based Medicine School of Basic Medical Sciences Lanzhou University Lanzhou Gansu Province China Sheng-Ping Yang the First Clinical Medical College of Lanzhou University China Jing-Yuan Li Pingliang People's Hospital Pingliang China |
| Affiliation: | Sheng-Ping Yang,Jing-Yuan Li,Peng Zhang,Jin-Qiu Yuan,Ya-Li Liu,Center for Evidence-Based Medicine,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,Gansu Province,China Sheng-Ping Yang,the First Clinical Medical College of Lanzhou University,China Jing-Yuan Li,Pingliang People's Hospital,Pingliang 744000,China |
| Abstract: | AIM:To evaluate the efficacy of telbivudine in the treatment of chronic hepatitis B.METHODS:Based on the principles and methods for Cochrane systematic reviews,we searched the Cochrane Library,PubMed,EMBASE,Chinese Bio-medicine Database,China Journal Full-text Database,VIP database,as well as websites of clinical trial registries and search engine Google.Randomized controlled trials(RCTs) or cross-over trials of telbivudine for chronic hepatitis B were included.We assessed the quality of the included trials... |
| Keywords: | Telbivudine Chronic hepatitis B Systematic review |
| 本文献已被 CNKI 等数据库收录！ | |