| 疏肝健脾方药对NASH大鼠心脏舒张功能及炎症因子的影响 |
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| 引用本文： | 王文晶,杨钦河,冯高飞,王彦平,何秀敏,张玉佩,杨雪萍,闫海震,黄进,李光秋,赵亚凤,杨晓蕾,沈灿宏.疏肝健脾方药对NASH大鼠心脏舒张功能及炎症因子的影响[J].世界华人消化杂志,2011(25):2615-2622. |
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| 作者姓名： | 王文晶 杨钦河 冯高飞 王彦平 何秀敏 张玉佩 杨雪萍 闫海震 黄进 李光秋 赵亚凤 杨晓蕾 沈灿宏 |
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| 作者单位： | 暨南大学医学院;河南省偃师市人民医院消化内科; |
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| 基金项目： | 国家自然科学基金资助项目,No.30973694; 国家大学生创新性实验计划基金资助项目,No.091055930~~ |
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| 摘 要： | 目的:探讨疏肝健脾方药对非酒精性脂肪性肝炎(nonalcoholic steatosis hepatitis,NASH)合并心脏舒张功能不全大鼠干预的作用机制.方法:采用高脂饲料喂养复制NASH大鼠实验模型,各药物组分别灌服疏肝方、健脾方和综合方(疏肝方和健脾方的合方)进行干预,16 wk后用Visual Sonics...
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| 关 键 词： | 非酒精性脂肪性肝炎 心脏舒张功能 炎症因子 高分辨率小动物超声诊断仪 大鼠 |
Effect of Shuganjianpifang on cardiac diastolic function and inflammatory factors in rats with nonalcoholic steatosis hepatitis |
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| Wen-Jing Wang,Qin-He Yang,Gao-Fei Feng,Yan-Ping Wang,Xiu-Min He,Yu-Pei Zhang,Hai-Zhen Yan,Jin Huang,Guang-Qiu Li,Ya-Feng Zhao,Xiao-Lei Yang,Can-Hong Shen,School of Medicine,Jinan University,Guangzhou ,Guangdong Province,China Xue-Ping Yang.Effect of Shuganjianpifang on cardiac diastolic function and inflammatory factors in rats with nonalcoholic steatosis hepatitis[J].World Chinese Journal of Digestology,2011(25):2615-2622. |
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| Authors: | Wen-Jing Wang Qin-He Yang Gao-Fei Feng Yan-Ping Wang Xiu-Min He Yu-Pei Zhang Hai-Zhen Yan Jin Huang Guang-Qiu Li Ya-Feng Zhao Xiao-Lei Yang Can-Hong Shen School of Medicine Jinan University Guangzhou Guangdong Province China Xue-Ping Yang |
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| Institution: | Wen-Jing Wang,Qin-He Yang,Gao-Fei Feng,Yan-Ping Wang,Xiu-Min He,Yu-Pei Zhang,Hai-Zhen Yan,Jin Huang,Guang-Qiu Li,Ya-Feng Zhao,Xiao-Lei Yang,Can-Hong Shen,School of Medicine,Jinan University,Guangzhou 510632,Guangdong Province,China Xue-Ping Yang,Department of Gastroenterology,Yanshi City People's Hospital,Yanshi 471900,Henan Province,China |
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| Abstract: | AIM: To investigate the effect of Shuganjianpifang on cardiac diastolic dysfunction in rats with nonalcoholic steatosis hepatitis (NASH) and to explore the possible mechanisms involved. METHODS: NASH was induced in rats by feeding a high-fat diet. Rats were divided into eight groups: normal control group, model group, high- and low-dose Ganfang, Pifang and Shuganjianpifang groups. After treatment for 16 weeks, stroke volume (SV), left ventricular ejection fraction (LVEF), and left ventricular diameter (LVFS... |
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| Keywords: | Nonalcoholic steatosis Cardiac diastolic function Inflammatory factors High-resolution in vivo imagine system Rat |
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