| Brg1及VEGF信号通路相关蛋白在Peutz-Jeghers综合征中的表达及意义 |
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| 引用本文： | 刘金霞,周平,胡志民,毛高平. Brg1及VEGF信号通路相关蛋白在Peutz-Jeghers综合征中的表达及意义[J]. 世界华人消化杂志, 2011, 0(23): 2461-2466 |
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| 作者姓名： | 刘金霞 周平 胡志民 毛高平 |
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| 作者单位： | 中国人民解放军空军总医院肿瘤放疗科;郑州大学第二附属医院神经外科;中国人民解放军空军总医院消化内科; |
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| 摘 要： | 目的:检测染色质重构复合物核心催化亚基(Brgl)及VEGF信号通路相关蛋白在Peutz-Jeghers综合征(PJS)中的表达,探讨其与PJS息肉发生发展的关系.方法:应用免疫组织化学染色技术分析72枚PJS息肉、12例正常小肠黏膜及30例小肠癌中Brgl、VEGF、COX-2蛋白的表达和分布,比较其在三种组织表达程...
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| 关 键 词： | Peutz-Jeghers综合征 染色质重构复合物核心催化亚基 血管内皮生长因子 免疫组织化学 |
Expression of Brg1,VEGF and COX-2 in Peutz-Jeghers syndrome |
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| Jin-Xia Liu,Ping Zhou. Expression of Brg1,VEGF and COX-2 in Peutz-Jeghers syndrome[J]. World Chinese Journal of Digestology, 2011, 0(23): 2461-2466 |
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| Authors: | Jin-Xia Liu Ping Zhou |
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| Affiliation: | Jin-Xia Liu,Ping Zhou,Department of Radiation Oncology,The General Hospital of Air Force of Chinese PLA,Beijing 100142,China Zhi-Min Hu,The Second Affiliated Hospital Of Zhengzhou University,Zhengzhou 450014,Henan Province,China Gao-Ping Mao,Department of Digestive Disease,China |
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| Abstract: | AIM:To detect the expression of brahma-related gene 1(Brg1),vascular endothelial growth factor(VEGF) and cyclooxygenase 2(COX-2) proteins in Peutz-Jeghers syndrome(PJS) and to analyze their clinical significance.METHODS:Immunohistochemistry was used to detect the expression of Brg1,VEGF and COX-2 proteins in 72 PJS samples,12 normal small intestinal mucosal tissue samples and 30 cancer tissue samples.RESULTS:The positive rates of Brg1,VEGFand COX-2 expression were significantly higher in PJS than in normal ... |
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| Keywords: | Peutz-Jeghers syndrome Brahmarelated gene 1 Vascular endothelial growth factor Immunohistochemistry |
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