| 胃旁路术对GK大鼠糖代谢影响及其与Ghrelin的关系 |
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| 引用本文： | 曹超,曾荣,张鹏,周晓磊,尤胜义.胃旁路术对GK大鼠糖代谢影响及其与Ghrelin的关系[J].世界华人消化杂志,2011(26). |
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| 作者姓名： | 曹超 曾荣 张鹏 周晓磊 尤胜义 |
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| 作者单位： | 天津医科大学总医院普通外科;天津市南开医院; |
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| 摘 要： | 目的:观察胃旁路术(gastric bypass,GBP)对非肥胖型2型糖尿病大鼠(Goto-Kakizaki rats;GK大鼠)血糖的影响,并探讨其机制.方法:GK大鼠20只,Wistar大鼠10只,均为雄性.分为GK手术组、GK假手术组和Wistar假手术组,每组10只.手术组行胃旁路术.测定术前1wk及术后第1、2、4、8、12wk各组大鼠的空腹血糖(FPG)、糖化血红蛋白(HbAlc)和血清胰岛素(INS),并同期检测血清Ghrelin水平.结果:术后第12周,GK手术组大鼠FPG和HbAlc分别由术前的11.36mmol/L±1.14mmol/L和8.91%±0.36%下降到8.36±0.62mmol/L和6.35%±0.46%,血清INS由术前32.76mIU/L±2.37mIU/L上升到55.14mIU/L±5.45mIU/L,而Ghrelin由术前928.53ng/L±58.66ng/L下降到367.83ng/L±27.78ng/L,差异均有统计学意义(P<0.05).结论:GBP可以明显改善GK大鼠的糖代谢,其作用机制可能与降低Ghrelin水平,进而促进胰岛素分泌有关.
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| 关 键 词： | 2型糖尿病 胃旁路术 GK大鼠 糖代谢 Ghrelin |
Gastric bypass surgery improves glucose metabolism possibly by decreasing ghrelin levels in Goto-Kakizaki rats |
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| Chao Cao,Peng Zhang,Xiao-Lei Zhou,Sheng-Yi You.Gastric bypass surgery improves glucose metabolism possibly by decreasing ghrelin levels in Goto-Kakizaki rats[J].World Chinese Journal of Digestology,2011(26). |
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| Authors: | Chao Cao Peng Zhang Xiao-Lei Zhou Sheng-Yi You |
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| Institution: | Chao Cao,Peng Zhang,Xiao-Lei Zhou,Sheng-Yi You,Department of General Surgery,Tianjin Medical University General Hospital,Tianjin 300052,China Rong Zeng,Tianjin Nankai Hospital,Tianjin 300100,China |
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| Abstract: | AIM:To investigate the influence of gastric bypass(GBP) surgery on glucose metabolism in Goto-Kakizaki(GK) rats and to explore the possible mechanisms involved.METHODS:Twenty male GK rats and 10 male Wistar rats were randomized into three groups:GK operation group,GK sham operation group and Wistar sham operation group.The GK operation group underwent gastric bypass surgery.The levels of fasting plasma glucose(FPG),glycosylated hemoglobin(HbAlc),serum insulin(INS) and ghrelin were monitored 1 week before su... |
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| Keywords: | Type 2 diabetes mellitus Gastric bypass Goto-Kakizaki rats Glucose metabolism Ghrelin |
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