|
|||||
|
|
| 肝星状细胞的可塑性及其对肝纤维化的意义 | |
| 引用本文： | 张贺吉,吴江峰,柳长柏. 肝星状细胞的可塑性及其对肝纤维化的意义[J]. 世界华人消化杂志, 2011, 0(33) |
| 作者姓名： | 张贺吉 吴江峰 柳长柏 |
| 作者单位： | 三峡大学分子生物学研究所;三峡大学医学院; |
| 基金项目： | 国家自然科学基金资助项目,No.81070348; 湖北省卫生厅青年科技人才基金资助项目,No.QUX2010-28 |
| 摘 要： | 在肝纤维化形成过程中,肝星状细胞(hepatic stellate cells,HSC)发挥着重要的作用.基础和临床研究结果显示,在特殊的内环境因素的影响下HSC具有朝多方向分化的潜能.对HSC命运的干预能够在一定程度上预防肝纤维化的发生,甚至逆转肝纤维化,因此HSC的可塑性研究可能为慢性肝病治疗开辟一条新途径.本文就HSC的起源、结构、可塑性及其对肝纤维化的潜在治疗意义作一综述. |
| 关 键 词： | 肝星状细胞 肝纤维化 干细胞 分化 |
Plasticity of hepatic stellate cells: implications for the treatment of hepatic fibrosis |
|
| He-Ji Zhang,Chang-Bai Liu. Plasticity of hepatic stellate cells: implications for the treatment of hepatic fibrosis[J]. World Chinese Journal of Digestology, 2011, 0(33) | |
| Authors: | He-Ji Zhang Chang-Bai Liu |
| Affiliation: | He-Ji Zhang,Chang-Bai Liu,Institute of Molecular Biology,China Three Gorges University,Yichang 443002,Hubei Province,China Jiang-Feng Wu,Medical College,China |
| Abstract: | Activation of hepatic stellate cells (HSCs) plays an important role in hepatic fibrogenesis. More and more experimental and clinical data have shown that HSCs have the capacity of multidirectional differentiation in special niches. Hepatic fibrosis may be prevented and reversed in part, if not all, by changing HSC fate. Thus, the research of HSC plasticity may break a new path for therapy of chronic hepatic diseases. This review aims to elucidate the origin, structure and plasticity of HSCs, and identify HS... |
| Keywords: | Hepatic stellate cells Hepatic fibrosis Stem cell Differentiation |
| 本文献已被 CNKI 等数据库收录！ | |