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| 核PTEN和Survivin蛋白在胃癌组织芯片中的表达及意义 | |
| 引用本文： | 王晓茹,李小宁,白光辉,郭云娣. 核PTEN和Survivin蛋白在胃癌组织芯片中的表达及意义[J]. 世界华人消化杂志, 2011, 0(28) |
| 作者姓名： | 王晓茹 李小宁 白光辉 郭云娣 |
| 作者单位： | 苏州卫生职业技术学院苏州检验医学生物技术重点实验室;苏州市立医院; |
| 摘 要： | 目的:探讨核PTEN和Survivin蛋白在胃癌组织芯片中的表达、临床病理学特征及其意义.方法:在116例胃癌35例正常胃黏膜组织芯片上,应用免疫组织化学En Vision法检测核PTEN和Survivin表达水平,分析核PTEN和Survivin在胃癌的表达与患者淋巴结转移状态、Lauren's分型等的关系及其相互关系.结果:核PTEN和Survivin在正常胃黏膜组织中表达率为100%,核PTEN在胃癌组织中的阳性表达率为51.7%(60/116):Survivin的阳性表达率为44.0%(51/116),核PTEN和Survivin与患者淋巴结转移状态相关(P<0.05),同时,核PTEN还和肿瘤分化程度、Lauren's分型密切相关(P<0.05).核PTEN和Survivin二者之间呈正相关(r=0.088,P=0.001).结论:胃癌组织中存在核PTEN和Survivin低表达:同时检测胃癌组织中的核PTEN和Survivin的表达对判断肿瘤的恶性程度和估计预后有一定意义. |
| 关 键 词： | 胃癌 第10号染色体同源缺失性磷酸酶-张力蛋白基因 Survivin 组织芯片 |
Signif icance of expression of nuclear PTEN and survivin in gastric cancer |
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| Xiao-Ru Wang,Xiao-Ning Li,Yun-Di Guo,Suzhou Health College,Suzhou Key Laboratory of Biotechnology for Laboratory Medicine,Suzhou ,Jiangsu Province,ChinaGuang-Hui Bai,Suzhou Municipal Hospital,Suzhou ,China. Signif icance of expression of nuclear PTEN and survivin in gastric cancer[J]. World Chinese Journal of Digestology, 2011, 0(28) | |
| Authors: | Xiao-Ru Wang Xiao-Ning Li Yun-Di Guo Suzhou Health College Suzhou Key Laboratory of Biotechnology for Laboratory Medicine Suzhou Jiangsu Province ChinaGuang-Hui Bai Suzhou Municipal Hospital Suzhou China |
| Affiliation: | Xiao-Ru Wang,Xiao-Ning Li,Yun-Di Guo,Suzhou Health College,Suzhou Key Laboratory of Biotechnology for Laboratory Medicine,Suzhou 215009,Jiangsu Province,ChinaGuang-Hui Bai,Suzhou Municipal Hospital,Suzhou 215008,China |
| Abstract: | AIM:To investigate the expression of nuclear PTEN and survivin in gastric cancer and to evaluate their clinicopathological significance.METHODS:The expression of nuclear PTEN and survivin was measured in 116 cases of gastric cancer and 35 cases of normal gastric mucosa tissue on tissue array sections by EnVision immunohistochemical method.The relationship of their expression with lymph node metastasis and Lauren's classification,as well as the correlation between nuclear PTEN and survivin expression were ev... |
| Keywords: | Gastric cancer Phosphatase and tensin homolog deleted on chromosome ten Survivin Tissue microarray |
| 本文献已被 CNKI 等数据库收录！ | |