A case of myelodysplastic syndrome with high platelet counts and a t(3;8)(q26;q24) |
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| Authors: | F Mertens B Johansson R Billstr?m L Engquist F Mitelman |
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| Affiliation: | 1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA;2. Baylor Miraca Genetics Laboratories, Houston, Texas, USA;3. Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA;1. Cell Biology Section, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, NC 27709, USA;1. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, United States;2. Cytogenetic Technology Program, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States;3. Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States |
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| Abstract: | ![]()
A 62-year-old male patient with refractory anemia with excess of blasts had a t(3;8)(q26;q24) as an acquired chromosomal abnormality in the bone marrow. This aberration has not been previously reported as a sole anomaly in any type of neoplasm, including myelodysplastic or myeloproliferative disorders. The findings of disturbed thrombocytopoiesis with high platelet counts and micromegakaryocytes in the bone marrow support the idea that alteration of the transferrin receptor gene, localized to 3q26, may be of pathogenetic significance. |
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