|
|||||
|
|
Influence of structural variations on drug release from lipid/polyethylene glycol matrices |
|
| Authors: | Maike Windbergs Clare Joanna Strachan Peter Kleinebudde |
| Affiliation: | aInstitute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetsstr. 1, 40225 Düsseldorf, Germany;bCentre for Drug Research, University of Helsinki, Viikinkaari 5E, 00014 University of Helsinki, Finland;cSchool of Pharmacy, University of Otago, 18 Frederick Street, Dunedin 9054, New Zealand |
| Abstract: | Different combinations of monoacid triglycerides and polyethylene glycol powders of different molecular weights were successfully extruded below their melting temperatures as a basis for oral dosage forms. The incorporated polyethylene glycols exhibiting different mean molecular weights were compared with respect to their effect on the dissolution rate for a model drug, and a mean molecular weight of 10,000 resulted in the most advantageous characteristics (fastest dissolution). Triglycerides with different fatty acid chain lengths provided additional options for the extrusion temperature which is beneficial for temperature sensitive active pharmaceutical ingredients. To obtain stable extrudates with desirable and reproducible dissolution characteristics a good understanding of the underlying processes during processing and storage is mandatory. |
| Keywords: | Solid lipid extrusion Dissolution Polyethylene glycol Triglyceride Chain length Molecular weight |
| 本文献已被 ScienceDirect 等数据库收录！ | |