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AA amyloidosis associated with systemic lupus erythematosus |
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| Authors: | E. J. ter Borg S. Janssen M. H. van Rijswijk J. Bijzet P. E. de Jong J. D. Elema C. G. M. Kallenberg |
| Affiliation: | (1) Department of Internal Medicine, University Hospital, Oostersingel 59, NL-9713 EZ Groningen, The Netherlands;(2) Department of Rheumatology, University Hospital, Oostersingel 59, NL-9713 EZ Groningen, The Netherlands;(3) Department of Nephrology, University Hospital, Oostersingel 59, NL-9713 EZ Groningen, The Netherlands;(4) Department of Pathology, University Hospital, Oostersingel 59, NL-9713 EZ Groningen, The Netherlands;(5) Department of Clinical Immunology, University Hospital, Oostersingel 59, NL-9713 EZ Groningen, The Netherlands |
| Abstract: | Summary A 54-year-old female with a 23-year history of systemic lupus erythematosus was admitted because of loss of renal function and nephrotic syndrome. Renal biopsy showed deposition of AA amyloid as demonstrated by Congo red staining and reactivity with protein AA-specific antibodies. Immune deposits were present in the mesangium and the glomerular basement membrane, but histopathological changes consistent with lupus nephritis were not detected. The rare association of systemic lupus erythematosus and amyloidosis is discussed in view of the characteristics of the acute phase reaction in systemic lupus erythematosus. |
| Keywords: | Systemic lupus erythematosus Amyloidosis Serum amyloid A protein C-reactive protein |
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