米非司酮用于高危人工流产的临床观察

目的:观察在高危人工流产术前应用米非司酮配伍米索前列醇后,减少手术并发症的临床效果。方法:将200例有高危倾向的人工流产的早孕妇女分为两组,A组100例,术前1天口服米非司酮100 mg,术前3 h阴道放置米索前列醇200μg。B组100例,术前不用任何药物,用传统宫颈扩张法进行人工流产术。观察两组术中扩宫的难易程度、手术时间、术中出血量、清宫次数以及人流综合征和子宫穿孔发生情况。结果:A组宫口扩张有效率100%,明显高于B组20%(20/100),P<0.01;A组术中无需使用局部麻醉(0/100),而B组则有70%的病人需加用局部麻醉,P<0.01;A组术中出血为(18.5±9.5)ml,也少于B组(28.2±10.5)ml,P<0.01。A组手术时间(5±3.5)min、B组(20±5)minP<0.01。A组无1例并发症。B组10例人流综合征。1例疑穿孔,2例二次清宫。结论:高危人工流产术前应用米非司酮配伍米索前列醇,能有效减少患者痛苦,缩短手术时间,出血量少,避免并发症,适合基层推广使用。

Clinical effect of mifepristone and misoprostol combined with the high-risk women on missed abortion

Objective: To observe the curative effect of the tendency of high-risk women induced abortion under the application of mifepristone and misoprostol.Methods:A total of high-risk of 200 women falls into 2 groups at random.To compare flabby of cervix uteri orifice,the bleeding volume,and the operation time,the treated group takes a total 100mg mifepristone 24 hours before the operation and 200 ug misoprostol 3 hours before operation,while the control group is directly operated on.Results:The obvious difference lies in the degree of flabby of cervix uteri orifice between the two groups(P<0.01);the bleeding volumes,operation times also differ greatly between the two groups(P<0.05).Conclusion After patients taking mifepristone and misoprostol on the induced operation,the cut,the bleeding volume and operation time is obviously decreased,which brings more safety to the induce abortion.Conclusion: In induced abortion of high-risk women,the application of mifepristone and misoprostol is worth popularizing.